- Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates
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(Matrix Presented) A double diastereotopic differentiation strategy on a phosphonoacetate template is described. The approach utilizes Rh2(OAc)4-catalyzed intramolecular cyclopropanation (ICP) employing the (R)-pantolactone auxiliary in the ester functionality of the phosphonoacetate. The olefinic diastereofacial selectivity is governed by inherent electronic and steric interactions in the reacting carbene intermediate, while the group selectivity is dictated by the chiral auxiliary. This approach is being developed as an effective method to access bicyclic P-chiral phosphonates.
- Moore, Joel D.,Sprott, Kevin T.,Wrobleski, Aaron D.,Hanson, Paul R.
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- Method for preparing unsaturated propyl phosphite ester and unsaturated propyl phosphate
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The invention relates to a method for preparing unsaturated propyl phosphite ester or unsaturated propyl phosphate. The unsaturated propyl phosphite ester is selected from triallyl phosphite and tripropargyl phosphite, and the unsaturated propyl phosphate is selected from triallyl phosphate and tripropargyl phosphate. The method comprises the steps: enabling phosphorus trichloride or phosphorus oxychloride to react with allyl ester to form triallyl phosphite or triallyl phosphate; or enabling phosphorus trichloride or phosphorus oxychloride to react with propargyl ester to form propargyl phosphite or propargyl phosphate. The method for preparing unsaturated propyl phosphite ester or unsaturated propyl phosphate does not need any catalyst, and a by-product acyl chloride compound has a low boiling point and is easy to separate so that the unsaturated propyl phosphite ester or unsaturated propyl phosphate with high yield and high purity can be obtained.
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Paragraph 0065-0068
(2019/08/15)
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- Xanthene dye compounds and photoresist composition containing the same
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The present invention relates to a xanthene-based dye compound and a photoresist composition containing the same, and more specifically, to a xanthene-based dye compound capable of realizing excellent heat resistance, light resistance, chemical resistance, a residual film ratio, developing ability, and strength while having improved solubility with respect to a solvent; and to a photoresist composition containing the same.COPYRIGHT KIPO 2017
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Paragraph 0107; 0115; 0116
(2018/02/10)
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- The composite body deproteinizing chitosanoligosaccharide-
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Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
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Page/Page column 87
(2016/10/09)
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