- Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant
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The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.
- Sdahl, Mark,Conrad, Jürgen,Braunberger, Christina,Beifuss, Uwe
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p. 19549 - 19559
(2019/07/05)
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- Synthesis of (± )trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4, 5-trimethoxyphenyl) tetrahydrofuran
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The synthesis of a potent platelet activating factor is described utilising commercially available acetovanillone and ethyl 3,4,5-trimethoxybenzoylacetate.
- Balram,Ram,Ram, S. Raghu
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p. 2059 - 2062
(2007/10/03)
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- PHARMACEUTICAL FORMULATIONS USEFUL TO TREAT INFLAMMATORY AND IMMUNE DISORDERS
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A pharmaceutical formulation is provided for the treatment of inflammatory and/or immune disorders, particularly those mediated by platelet activating factor (“PAF”) or a product of 5-lipoxygenase. The formulation, in one embodiment, is an essentially anhydrous ointment containing an active agent selected from the group consisting of 2,5-diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines, and an enhancer composition containing one or more C3-18 esters such as diethyl succinate, propylene carbonate, diisopropyl adipate and glyceryl triacetate. In another embodiment, the formulation is a cream, gel, lotion, oil, or the like, containing the: active agent in crystalline form. The invention also encompasses the novel crystalline form of the active agent, and methods for using the formulations to treat individuals with inflammatory and/or immune disorders. Also encompassed is use of isopropyl alcohol (IPA) to enhance stability of the active agent and pharmaceutical formulations.
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- Synthesis and antimicrobial activity of 1-[3-methoxy-4-[4-chlorophenylthioethoxy]-5-iodophenyl]prop-2-ene-1-one and its intermediates
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The synthesis and antimicrobial activity of 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]prop-2-ene-1-one, which is used as an important intermediate for the synthesis of 2.5-transdiaryltetrahydronfuran, are reported.
- Ram,Balram,Subhadra,Sai Prakash
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p. 120 - 123
(2007/10/03)
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- (±)-Trans-2-[3-methoxy-4-(4-chlorophenyl thioethoxy)-5-cyanophenyl]-5- (3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent PAF-receptor antagonist
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The synthesis of (±)-trans-2-[3-methoxy-4- (chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran from commercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described.
- Ram,Balram,Sai Prakash
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p. 10163 - 10172
(2007/10/03)
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