Identification of inhibitors of checkpoint kinase 1 through template screening
Checkpoint kinase 1 (CHK1) is an oncology target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment
Matthews, Thomas P.,Klair, Suki,Burns, Samantha,Boxall, Kathy,Cherry, Michael,Fisher, Martin,Westwood, Isaac M.,Walton, Michael I.,McHardy, Tatiana,Cheung, Kwai-Ming J.,Van Montfort, Rob,Williams, David,Aherne, G. Wynne,Garrett, Michelle D.,Reader, John,Collins, Ian
experimental part
p. 4810 - 4819
(2010/03/01)
MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS
The present invention pertains generally to the field of therapeutic compounds, and mor specifically to certain morpholino-substituted bicydoheteroaryl compounds (referred to herein as MBHA compounds), of the following formula: and especially certain morp
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Page/Page column 97
(2008/12/06)
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