- Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles
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Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.
- Wang, Xuetong,Wang, Yin,Liu, Xiaoling,He, Tingshu,Li, Lingli,Wu, Huili,Zhou, Shangjun,Li, Dan,Liao, Siwei,Xu, Ping,Huang, Xing,Yuan, Jianyong
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supporting information
(2021/10/14)
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- Efficient and convenient protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using HClO4-SiO2 as a heterogeneous recyclable catalyst
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Silica-supported perchloric acid (HClO4SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.
- Tadikonda, Ramu,Nakka, Mangarao,Gajula, Mahaboob Basha,Rayavarapu, Srinuvasarao,Gollamudi, Padma Rao,Vidavalur, Siddaiah
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supporting information
p. 1978 - 1986
(2014/07/07)
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- A simple and straightforward protocol to 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids
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A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acids and amidoximes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NM1 B) has been employed to synthesize a variety of 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields. The methodology has been applied for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
- Ramu, Tadikonda,Prasanthi, Sarakula,Mangarao, Nakka,Basha, Gajula Mahaboob,Srinuvasarao, Rayavarapu,Siddaiah, Vidavalur
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supporting information
p. 722 - 724
(2013/07/26)
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- THERMAL REACTIONS OF ARYLAMIDOXIMES
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The effect of heat on arylamidoximes, 1a-g, has been examined.When acetic acid was used as solvent, amidoximes, 1a-g, provided three products, viz., 3,5-bis-aryl-1,2,4-oxadiazoles, 2a-g, 3-aryl-5-methyl-1,2,4-oxadiazoles, 3a-g, and a small quantity of an
- Leite, Lucia F. C. da Costa,Srivastava, Rajendra M.,Cavalcanti, Alexandre P.
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p. 203 - 210
(2007/10/02)
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- The Nitration of Imidazopyridines
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Imidazopyridines in acetic acid solution are readily nitrated by nitric acid-sulphuric acid, although in some instances treatment of the base hydrogensulphate with nitric acid-acetic acid is preferred.Nitration occurs most readily in the 1-position, but 3-nitration occurs if the 1-position is already substituted.
- Glover, Edward E.,Peck, Leonard, W.
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p. 959 - 962
(2007/10/02)
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