- Tetrahydropyridino aromatic heterocyclic inhibitor as well as preparation method and application thereof
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The invention discloses a hepatitis B virus surface antigen (HBsAg) secretion and HBV DNA generation inhibitor, provides a tetrahydropyridino aromatic heterocyclic compound with a structure shown in aformula (I), a stereoisomer, a tautomer or pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, and also provides a pharmaceutical composition of the pharmaceutically acceptable salt of the compound. The tetrahydropyridino aromatic heterocyclic compound can be used for treating and preventing viruses and related diseases.
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Paragraph 0120; 0122; 0123; 0124
(2021/02/10)
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- NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.
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Page/Page column 56
(2016/07/27)
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- TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS
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The present invention provides tetrahydropyridopyrimidines and tetrahydropyridopyridines having the general formula (I) wherein R1, R2, U, W, X, Y and Z are as described herein, as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment and prophylaxis of hepatitis B virus infections.
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Page/Page column 83; 84
(2016/11/21)
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- CALCILYTIC COMPOUNDS
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Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
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Page/Page column 36
(2008/12/06)
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