Aryl- and Alkynyltri-isopropoxytitanium Reagents in Regioselective Carbon-Carbon Bond Formation in Azines
Regioselective arylation in the 4-position in pyridines results from 1:1-adduct formation between an aryltriisopropoxytitanium reagent and N-isobutyloxycarbonyl- or an N-silyloxymethyl-3-cyanopyridinium salt after successive DDQ dehydrogenation and cleavage of the 1-substituent.Complete regioselectivity for new C-C bond formation in the 4-position results in the adduct formation between aryl- and phenylethynyltri-isopropoxytitanium reagents and pyrimidin-2(1H)-ones; with ethynyltriisopropoxytitanium the new C-C bond formation occurs at the 6-position.
Gundersen, Lise-Lotte,Rise, Frode,Undheim, Kjell
p. 5647 - 5656
(2007/10/02)
Regioselectivity in the Reactions of Aryltri-isopropoxytitanium with Pyrimidinones.
Complete regioselectivity is observed in the 1:1-adduct formation between aryltri-isopropoxytitanium reagents and pyrimidin-2(1H)ones: the new carbon-carbon-bond is formed at C-4.Dehydrogenation gives the arylated, fully conjugated heterocycle.
Rise, Frode,Undheim, Kjell
p. 1997 - 2000
(2007/10/02)
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