- Myo-inositol orthoformates
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This invention provides the 4-mono-anion of myo-inositol orthoformate, and describes a process for preparing this anion as well as the use of this anion in the preparation of a variety of mono- and poly-phosphate derivatives of myo-inositol.
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- The Total Synthesis of myo-Inositol Phosphates via myo-Inositol Orthoformate
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Novel selective alkylations of myo-inositol orthoformate (4) have been used to prepare a series of protected myo-inositol derivatives, (5a-e), (7), (10), (12), and (16).These intermediates have been used in efficient total syntheses of myo-inositol 2-phosphate, (9); myo-inositol 4-phosphate, (6); myo-inositol 1,3-bisphosphate, (18); and myo-inositol 1,3,4,5-tetrakisphosphate (14).This report represents the first total synthesis of the important natural metabolites (14) and (18) and significantly improved methods of preparation of (6) and (9).
- Billington, David C.,Baker, Raymond,Kulagowski, Janusz J.,Mawer, Ian M.,Vacca, Joseph P.,et al.
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p. 1423 - 1429
(2007/10/02)
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- Synthesis of myo-Inositol 1,3,4,5-Tetraphosphate and myo-Inositol 1,3-Biphosphate
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myo-Inositol 1,3,4,5-tetraphosphate, myo-inositol 3,4-biphosphate, and myo-inositol 4-phosphate have been prepared via routes in which a key step is a novel, highly regioselective monooalkylation of myo-inositol orthoformate.
- Billington, David C.,Baker, Raymond
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p. 1011 - 1013
(2007/10/02)
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