A large-scale synthesis of [MeTyr, MeArg, D-Leu]Dynorphin A-(1-8)-NHEt (E-2078) by application of the trifluoroacetic acid-pentamethylbenzene deprotecting procedure in the final stage
Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues
In order to study the structure-activity relationships of dynorphin A-(1-8) amide [Dyn(1-8)-NH2], 20 analogues were synthesized by the solution method. Their biological activities were determined in the three bioassays [guinea pig ileum (GPI),