Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents
A series of sulfanilamide Schiff base derivatives (1 to 15) have been designed as potential antitubulin agents depending on the chemical structures of combretastatine A-4 and isoquinoline sulfamate (antimitotic agents under investigation). The designed co
Mohamed, Sofian S.,Tamer, Abdalkarem R.,Bensaber, Salah M.,Jaeda, Mousa I.,Ermeli, Nouri B.,Allafi, Aemen Ali,Mrema, Ibrahim A.,Erhuma, Mabrouk,Hermann, Anton,Gbaj, Abdul M.
p. 813 - 822
(2013/09/23)
Synthesis and antidiabetic performance of β-amino ketone containing nabumetone moiety
We wish to report the further design and improved synthesis that resulted in two series of target molecules, TM-1 and TM-2, with remarkably simplified structures containing β-amino ketone of discrete nabumetone moiety. These were obtained via a 'one-pot,
Microwave-assisted, solvent-free and parallel synthesis of some novel substituted imidazoles of biological interest
Solvent free microwave assisted synthesis of some novel substituted imidazoles of biological interest is reported. First, primary aromatic or heteryl amine was condensed with aryl or heteryl aldehydes to afford corresponding Schiff's base. The Schiff's base further on treatment with ammonium acetate (NH4OAC) and isatin using silica gel as the solid support, yielded the corresponding aryl imidazoles. In this paper a comparative study between the developed microwave method and conventional method is described. The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their antibacterial, anthelmintic, short-term anticancer and antitubercular activity. All the synthesized substituted imidazoles have shown good antibacterial activity against gram negative bacterial strains Klebsiella pneumoniae and Escherichia coli and moderate to good anthelmintic activity. The synthesized imidazole derivative possessed signifi-cant cytotoxic activity against Ehrlich's ascites carcinoma (EAC) cell lines. None of the compounds exhibited prominent antitubercular activity.
Sharma, Gyanendra Kumar,Pathak, Devender
experimental part
p. 375 - 380
(2011/02/25)
Microwave-assisted, solvent-free, parallel syntheses and elucidation of reaction mechanism for the formation of some novel tetraaryl imidazoles of biological interest
The microwave assisted, solvent free, parallel syntheses of title compounds is described in this protocol. Twelve new tetraaryl imidazoles, which are incorporated with the chemotherapeutic pharmaco- phores, have been synthesized by adopting one pot multic
Kumar, B. R. Prashantha,Sharma, Gyanendra Kumar,Srinath,Noor, Mohamed,Suresh,Srinivasa
experimental part
p. 278 - 284
(2009/07/05)
Carbonic anhydrase inhibitors. Part 35. Synthesis of Schiff bases derived from sulfanilamide and aromatic aldehydes: The first inhibitors with equally high affinity towards cytosolic and membrane-bound isozymes
A series of Schiff bases was prepared by reaction of sulfanilamide with substituted benzene- and heterocyclic aldehydes. The compounds were characterized by standard procedures, and were assayed as inhibitors of the zinc enzyme carbonic anhydrase (CA). Th
Supuran,Nicolae,Popescu
p. 431 - 438
(2007/10/03)
Preparation and antibacterial activity of 2-phenyl-3-(2',4'-diarylamino-s-triazin-6-yl)-5/H/CH3- carboxymethyl-4-thiazolidinone and 2-aryl-3-(p-aminosulphophenyl/2'- pyrimidylaminosulphophenyl)-p-carboxymethyl-4- thiazolidinones
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Kamdar,Chavda,Parikh
p. 298 - 301
(2007/10/02)
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