- 1,2-dicarbonyl compound and synthesis method thereof
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The invention discloses a method for synthesizing a 1,2-dicarbonyl compound (1,2-dicarbonylamide or alpha-diketone compound), wherein 1,2-dicarbonyl thioester compounds used as 1,2-dicarbonyl reagentsreact with amine compounds or boric anhydride compounds under appropriate conditions to respectively synthesize a series of 1,2-dicarbonyl compounds. According to the present invention, the 1,2-dicarbonyl compound is obtained by using the stable 1,2-dicarbonyl thioester compound as the dicarbonylation reagent through one-step construction under mild conditions, such that the disadvantage that thetraditional method uses the unstable alpha-carbonyl acyl chloride to synthesize the 1,2-dicarbonyl compound is avoided.
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Paragraph 0221-0224
(2019/10/01)
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- First total synthesis of N-(3-guanidinopropyl)-2-(4-hydroxyphenyl)-2- oxoacetamide
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The first total synthesis of the α-oxo amide-based natural product, N-(3-guanidinopropyl)-2-(4-hydroxyphenyl)-2-oxoacetamide (3), isolated from aqueous extracts of hydroid Campanularia sp., has been achieved. The α-oxo amide 12, prepared via the oxidative
- More, Satish S.,Raghunadh, Akula,Shankar, Ramanathan,Patel, Navin B.,Bhalerao, Dinesh S.,Syam Kumar, Unniaran K.
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p. 404 - 413
(2014/04/03)
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