Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media
1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent- free conditions on potassium fluoride impregnated alumina. Yields were dramatically improved in comparison with classical heating under the same conditions. (C) 2000 Published by Elsevier Science Ltd.
Márquez, Heiddy,Pérez, Eduardo R.,Plutín, Ana M.,Morales, Margarita,Loupy, André