- Selective sodium channel regulator as well as preparation and application thereof
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The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.
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Paragraph 0094-0095; 0111-0114
(2021/02/10)
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- mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY
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Described herein, inter alia, are compounds and methods useful for increasing autophagy.
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Paragraph 0621; 0623
(2020/07/25)
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- Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins
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The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
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Paragraph 0816; 0817; 0818; 0819; 0820
(2017/01/23)
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- Pyrimidine derivative, preparation method and applications thereof
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The present invention provides a pyrimidine derivative represented by a formula (I), or a pharmaceutically acceptable salt, a preparation method and applications thereof. According to the present invention, the pyrimidine derivative represented by the formula (I), or the pharmaceutically acceptable salt thereof has JAK kinase inhibition activity, particularly provides selective and high inhibition activity on JAK3 kinase, can be used for preparation of JAK3 kinase inhibitors, and can be used for preparation of drugs for preventing or treatment of diseases associated with abnormal JAK3 kinase activity so as to prevent or treat diseases associated with abnormal JAK3 kinase activity. The formula (I) is defined in the specification.
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Paragraph 0078; 0079; 0080
(2016/10/08)
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- Pyrimidine derivative, preparation method and applications thereof
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The present invention provides a pyrimidine derivative represented by a formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and applications thereof, wherein the pyrimidine derivative represented by a formula (I), or pharmaceutically acceptable salt thereof has JAK kinase inhibition activity, particularly provides selective and high inhibition activity on JAK3 kinase, can be used for preparation of a JAK3 kinase inhibitor, and can be used for preparation of drugs for prevention or treatment of diseases associated with abnormal JAK3 kinase activity so as to prevent or treat diseases associated with abnormal JAK3 kinase activity. The formula (I) is defined in the specification.
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Paragraph 0079-0081
(2016/11/17)
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- Preparation method and applications of aromatic heterocyclic compound adopted as selective JAK3 and/or JAK1 kinase inhibitor
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The present invention relates to an aromatic heterocyclic compound, a preparation method and applications thereof, wherein the structure of the compound is represented by a general formula (I), each group is defined in the specification, and the compound
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- CARBAZOLE AND CARBOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS, TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH AMYLOID OR AMYOLID-LIKE PROTEINS
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The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
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Page/Page column 168; 169
(2015/08/06)
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- Synthesis of quinoxaline derivatives from substituted acetanilides through intramolecular quaternization reactions
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The cyclization of 2-dialkylamino-2′-halogeno- and 2-chloro-2′-(dialkylamino)acetanilides to quinoxaline derivatives has been studied in detail. These reactions proceed, respectively, through intramolecular aromatic nucleophilic or aliphatic nucleophilic
- De Castro, Sonia,Chicharro, Roberto,Aran, Vicente J.
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p. 790 - 802
(2007/10/03)
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