Convenient and efficient microwave-assisted synthesis of a methyl derivative of the fused indoloquinoline alkaloid cryptosanguinolentine
An efficient synthesis of a methyl derivative of the indoloquinoline alkaloid cryptosanguinolentine based on microwave-assisted reactions is described. The microwave-assisted synthesis of an intermediate 4-hydroxy-2-methylquinoline yielded 86% of the desired product and other intermediates prepared yielded high % of products in shorter reaction times, under optimum conditions, as compared to traditional methods.
Gengan, Robert M.,Pandian, Pitchai,Kumarsamy, Chandraprakash,Mohan, Palathurai S.
Photo induced synthesis of methyl derivative of cryptosanguinolentine
A simpler method to synthesize methyl derivative of an alkaloid ciyprosanguinolentine is described. 4-Hydroxy-2- methylquinoline is iodized using iodine, potassium iodide and aqueous sodium hydroxide and dehydroxyhalogenated with phosphorous oxychloride. The respective anilinoquinoline is prepared and cyclized by UV irradiation. Upon selective methylation 5,6-dimethyl-5//-indolo[3,2-c]quinoline is produced which is utilized as a DNA intercalating agent.
Pitchai,Mohan,Gengan
experimental part
p. 692 - 696
(2009/12/24)
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