- SUBSTITUTED PYRIMIDINES
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Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
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Page/Page column 37
(2013/04/10)
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- UREAS IN ORGANIC SYNTHESIS. V. REACTIONS OF AROMATIC KETONES AND 1,2-DIKETONES WITH UREAS IN FORMIC ACID
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Urea in formic acid is a general and practical reagent for the reductive aminoformylation of benzophenones and fluoren-9-one in the synthesis of N-diarylmethylformamides, which exhibit antispasmodic activity.With benzophenone in formic acid 1,3-dimethylurea gives a high yield of N-methyl-N-benzhydrylformamide.Urea reacts selectively with benzil and benzoin, forming both the bicyclic bisurea and monocyclic nitrogen-containing heterocycles, depending on the temperature.It was proposed for the first time to use arylmethylenebisureas as reagents in reaction with benzil for the production of 1,5-diphenyl-2,4,6,8-tetraazabicyclooctane-3,7-dione or 2,4,5-triphenylimidazole.
- Bakibaev, A.A.,Yagovkin, A.Yu.,Filimonov, V.D.
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p. 1326 - 1331
(2007/10/02)
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