Control of the iodination reaction on activated aromatic residues in peptides
By using a slight molar excess of the IPy2BF4 reagent in an acid containing medium, activated aromatic residues on Tyr derivatives and peptides selectively react yielding, as major products, the monoiododerivatives; this level of reaction control cannot be achieved by other iodinating methods.
Espuna, Gemma,Arsequell, Gemma,Valencia, Gregorio,Barluenga, Jose,Perez, Marta,Gonzalez, Jose M.
Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells
Inhibition of growth hormone (GH) and prolactin (PRL) release from the anterior pituitary gland is mediated through somatostatin receptor subtypes sst2 and sst5. It has been found that somatostatin (SS) analogues that are selective for both receptor subty
Moore, Sandra Blaj,Van Der Hoek, Joost,De Capua, Antonia,Van Koetsveld, Peter M.,Hofland, Leo J.,Lamberts, Steven W. J.,Goodman, Murray,Taulane, Joseph P.
p. 6643 - 6652
(2007/10/03)
SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE
Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof.
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Page/Page column 24-25
(2008/06/13)
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