The present invention relates to novel xanthine derivatives of the formula (I) which are selectively antagonistic to an adenosine A 2 receptor, and pharmaceutically acceptable salts thereof. Formula (I): STR1 In the formula, R 1 and R 2 are the same or di
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(2008/06/13)
Adenosine A(2A) antagonists with potent anti-cataleptic activity
Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and S-position was found to dramatically potentiate the anti-cataleptic activity.