- ALKYL-AMINE HARMINE DERIVATIVES FOR PROMOTING BONE GROWTH
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In one aspect, the invention provides compounds of Formula I, and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I, Formula II, or Formula III. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease and cancer, using a compound of Formula I, Formula II, or Formula III.
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Paragraph 0405-0406
(2014/09/30)
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- Considerations to the synthesis of methadone-nitrile as well as isomethadone-nitrile, and related compounds
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The 2-chloro-1-dialkylamino-propanes 4a-d are reacted with diphenylacetonitrile under phase transfer conditions to give a mixture of the nitriles la-d and 2a-d. Both chloro-dialkylamino-1-phenyl-ethanes 7a-d and 8a-d lead to 4-dialkylamino-2,2,3-triphenyl-butyronitriles 6a-d.
- Unterhalt,Coesfeld
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p. 229 - 234
(2007/10/03)
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