Enzymatic resolution of benzothiazepine for the preparation of squalene synthetase inhibitors
A key intermediate with a 4,1-benzothiazepine skeleton, useful for the synthesis of potent squalene synthetase inhibitors, has been prepared via enzymatic resolution providing excellent yield and enantiomeric purity.
Yang, Xiaojing,Buzon, Leanne,Hamanaka, Ernie,Liu, Kevin K.-C.