Germanium(II)-mediated reductive Mannich-type reaction of α-bromoketones to N-alkylimines
(Chemical Equation Presented) A versatile metal: Germanium was effectively used in a novel and efficient method for the Mannich-type reaction between α-bromoketones and simple N-alkyl imines (see scheme). Germanium(II) acts as a reducing agent, forming a
Studies of selective Boc removal in the presence of silyl ethers
The selective removal of N-Boc protection can be obtained in the presence of either TBDMS or TBDPS ethers. On the basis of promising results from the literature, we first tried sonication, that failed, whereas the exclusive cleavage of the Boc group was successfully achieved by a saturated solution of HCl in ethyl acetate.
Cavelier, Florine,Enjalbal, Christine
p. 5131 - 5134
(2007/10/03)
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