Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15
The natural cytotoxic compounds dolastatins 10 and 15 exhibit great similarities in structure and in their biological activity profiles. Two compounds (1 and 2) formed by interchanging the dolaisoleuine residue of dolastatin 10 and the MeVal-Pro dipeptide
Poncet, Jo?l,Busquet, Magali,Roux, Florence,Pierré, Alain,Atassi, Ghanem,Jouin, Patrick
p. 1524 - 1530
(2007/10/03)
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