- A novel one-pot method for the synthesis of substituted furopyridines: Iodine-mediated oxidation of enaminones by tandem metal-free cyclization
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A novel iodine-mediated oxidative tandem cyclization reaction of simple enaminones has been developed for the synthesis of substituted furopyridines through C-C/C-N/C-O bond formation in a one-pot procedure. Substituted furopyridines are obtained in moder
- Yan, Rulong,Li, Xiaoni,Yang, Xiaodong,Kang, Xing,Xiang, Likui,Huang, Guosheng
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- Direct C-arylation of β-enamino esters and ketones with arynes
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(Chemical Equation Presented) An efficient, mild, and general method for the C-arylation of β-enamino esters and ketones with arynes has been developed. This methodology provides a facile and direct access to a variety of substituted aromatic β-enamino co
- Ramtohul, Yeeman K.,Chartrand, Anik
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- Phosphorescent ?C* Cyclometalated PtII Dibenzofuranyl-NHC Complexes - An Auxiliary Ligand Study
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Neutral ?C* cyclometalated PtII NHC complexes have recently emerged as a new class of phosphorescent emitters with high quantum efficiencies, short decay lifetimes and high thermal stability, which makes them promising candidates for OLED applications. Herein, we report investigations on the photophysical properties of seven new PtII complexes containing a chelating NHC dibenzofuranyl ligand (3-methyl-1-dibenzo[b,d]furan-4- ylimidazole) and a bidentate monoanionic auxiliary ligand. All complexes have been fully characterized including extensive NMR studies (COSY, HSQC, HMBC, NOESY, 195Pt NMR), three of them also by solid-state structures. The extraordinary influence of the auxiliary ligands on the photoluminescence properties is demonstrated by quantum yields ranging from 0 % to 91 % in amorphous PMMA films at room temperature. DFT calculations were performed in order to investigate the nature of the emissive states in more detail. Copyright
- Tronnier, Alexander,Nischan, Nicole,Metz, Stefan,Wagenblast, Gerhard,Münster, Ingo,Strassner, Thomas
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- Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines
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A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.
- Tang, Qiang,Yuan, Meng,Duan, Jiahui,Xu, Keke,Li, Ruxue,Xie, Mengqing,Kong, Shuwen,He, Xinwei,Shang, Yongjia
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supporting information
(2022/01/19)
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- Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
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Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochemical and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9 μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia.
- Ulven, Elisabeth Rexen,Quon, Tezz,Sergeev, Eugenia,Barki, Natasja,Brvar, Matjaz,Hudson, Brian D.,Dutta, Palash,Hansen, Anders H?jgaard,Bielefeldt, Line O.,Tobin, Andrew B.,McKenzie, Christine J.,Milligan, Graeme,Ulven, Trond
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p. 3577 - 3595
(2020/04/30)
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- Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters
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A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.
- Ma, Xingxing,Yu, Xiaoxia,Huang, Hua,Zhou, Yao,Song, Qiuling
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supporting information
p. 5284 - 5288
(2020/07/14)
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- Metal-Free Method for Direct Synthesis of Functionalized β-Ketoenamines
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A new method for direct synthesis of β-ketoenamines was developed by a BF3·OEt2-catalyzed cyclization of 1-iodoalkyne and α-keto acid followed by an amine-mediated ring-opening in one pot. Its metal-free conditions allowed the easy synthesis of those products bearing the transition metal-sensitive functional groups. Its three-component process achieved wide range of functionalized products.
- Zeng, Xiaobao,Liu, Chulong,Yang, Weiguang,Weng, Yunxiang,Wang, Xinyan,Hu, Yuefei
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p. 3656 - 3661
(2019/03/20)
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- Electrochemical behaviour of amino substituted β-amino α,β-unsaturated ketones: A computational chemistry and experimental study
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The synthesis, identification and electrochemical properties are reported here, for a series of five novel and seven known amino substituted β-amino α,β-unsaturated ketones (bidentate N,O-ligands) of the type CH3COCHC(NHR)CH3, where R = H, Ph, CH2Ph, CH(CH3)2, p-CF3-Ph or p-tBu-Ph (Series 1), as well as type PhCOCHC(NHR)CH3, where R = H, Ph, p-NO2-Ph, 3,5-di-Cl-Ph, 2-CF3-4-Cl-Ph, and also PhCOCHC(NHPh)CF3 (Series 2). The cyclic voltammograms measured in CH3CN, generally exhibit both a chemically and electrochemically irreversible reduction peak between ?1.2 V and ?3.1 V vs FcH/FcH+, producing an unstable radical anion, for most of these 1,3-amino ketones. Only ligands PhCOCHC(NHPh)CH3, PhCOCHC(NHPh)CF3 and PhCOCHC(NH(p-NO2-Ph))CH3, showed reversible electrochemical behaviour, at higher scan rates. Density functional theory (DFT) calculations proved the unpaired spin density in the radical anion to be distributed over the pseudo-aromatic O–C–C–C–N backbone of the 1,3-amino ketones, extending further over the phenyl rings of the phenyl-containing ligands. Various DFT calculated energies, such as the energy of the lowest unoccupied molecular orbital (the orbital into which the electron is added upon reduction), as well as the DFT calculated gas phase adiabatic electron affinities, relate linearly to the experimentally measured reduction potential. These obtained linear relationships confirmed that good communication via conjugation exists, between the R substituent on the amino group and the rest of the 1,3-amino ketone.
- Ngake, Tankiso Lawrence,Potgieter, Johannes Hermanus,Conradie, Jeanet
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p. 1070 - 1082
(2019/01/05)
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- Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines
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A facile, general, and economical synthesis of diversely functionalized pyrimidines has been realized under basic conditions via the copper-catalyzed cyclization of ketones with nitriles. The reaction proceeds via a novel pathway involving the nitriles ac
- Su, Lebin,Sun, Kang,Pan, Neng,Liu, Long,Sun, Mengli,Dong, Jianyu,Zhou, Yongbo,Yin, Shuang-Feng
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supporting information
p. 3399 - 3402
(2018/06/11)
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- Β-carbonyl enamines compound and as the application of the preparation of plant pathogenic bacteria antibacterial agent (by machine translation)
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The invention relates to a β-carbonyl compound and enamines preparation of plant pathogenic bacteria as the application of an antimicrobial agent. Commercially available antibacterial agent Mijunzhi as a positive control, the linear growth of the mycelium determination process 23 kind of target compound anthrax pathogenicbacteria the apple, corn curved spore pathogenic bacterium, pathogenic bacteria rice blast fungus, reducing bakanae disease of wheat, such as watermelon blighting pathogenicbacteria 5 common inhibiting activity of plant pathogenic fungi, the result shows that: the target compound has tries the fungus inhibiting effect of different degree. Compound 8, 11, 12, 14, 16 of the activity is better, for the majority of their pathogenic bacteria testing EC 50 half of the effect of the concentration value is higher than the positive control drug kresoxim-methyl. Especially compound 8 inhibition of anthrax pathogenicbacteria the apple active (EC 50 = 2.15μg/mL) compound and 12 the inhibitory activity of pathogenic bacterium curved spore (EC 50 = 9.14μg/mL) are Mijunzhi active (EC 50 = 15.45 & 76.06μg/mL) of 8 times, has potential development and application values. (by machine translation)
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Paragraph 0055; 0056; 0057; 0058; 0059; 0060; 0061; 0062
(2016/10/08)
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- Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes
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An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction of the products has been accomplished via the cascade generation of two C-C and
- Wan, Jie-Ping,Jing, Yanfeng,Hu, Changfeng,Sheng, Shouri
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p. 6826 - 6831
(2016/08/16)
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- Asymmetric Hydrogenation of Isoxazolium Triflates with a Chiral Iridium Catalyst
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The iridium catalyst [IrCl(cod)]2–phosphine–I2(cod=1,5-cyclooctadiene) selectively reduced isoxazolium triflates to isoxazolines or isoxazolidines in the presence of H2. The iridium-catalyzed hydrogenation proceeded in high-to-good enantioselectivity when an optically active phosphine–oxazoline ligand was used. The 3-substituted 5-arylisoxazolium salts were transformed into 4-isoxazolines with up to 95:5 enantiomeric ratio (e.r.). Chiral cis-isoxazolidines were obtained in up to 89:11 e.r., with no formation of their trans isomers, when the substrates had a primary alkyl substituent at the 5-position. The mechanistic studies indicate that the hydridoiridium(III) species prefers to deliver its hydride to the C5 atom of the isoxazole ring. The hydride attack leads to the formation of the chiral isoxazolidine via a 3-isoxazoline intermediate. Meanwhile, in the selective formation of 4-isoxazolines, hydride attack at the C5 atom may be obstructed by steric hindrance from the 5-aryl substituent.
- Ikeda, Ryuhei,Kuwano, Ryoichi
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p. 8610 - 8618
(2016/07/07)
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- Reactions of methyl ketones and (hetero)arylcarboxamides with N,N-dimethylacetamide dimethyl acetal. A simple metal-free synthesis of 2,4,6-trisubstituted pyridines
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Two metal-free syntheses of 2,4,6-trisubstituted pyridines 10a-m and 16a-j are described. N,N,6-Trimethyl-4-(substituted)pyridin-2-amines 10 were prepared from aryl or heteroaryl methyl ketones which were transformed with N,N-dimethylacetamide dimethyl ac
- Prek, Benjamin,Groelj, Uro,Kasuni, Marta,Zupani, Silvo,Svete, Jurij,Stanovnik, Branko
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p. 184 - 195
(2015/02/19)
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- Synthesis of 3-aminopyridin-2(1H)-ones and 1H-pyrido[2,3-b][1,4]oxazin- 2(3H)-ones
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The interaction of 1,3-diketones with chloroacetamide produced N-(3-oxoalkenyl)chloroacetamides. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol led to the formation of pyridin-2(1H)-ones, substituted with a py
- Fisyuk,Kulakov,Goncharov,Nikitina,Bogza,Shatsauskas
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p. 217 - 224
(2014/06/23)
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- Synthesis of 3-aminopyridin-2(1H)-ones and 1H-pyrido[2,3-b][1,4]oxazin-2(3H)-ones
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The interaction of 1,3-diketones with chloroacetamide produced N-(3-oxoalkenyl)chloroacetamides. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol led to the formation of pyridin-2(1H)-ones, substituted with a py
- Fisyuk,Kulakov,Goncharov,Nikitina,Bogza,Shatsauskas
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p. 217 - 224
(2015/09/28)
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- Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters
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A series of symmetrical and unsymmetrical 1,4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compound
- Radadiya, Ashish,Khedkar, Vijay,Bavishi, Abhay,Vala, Hardevsinh,Thakrar, Shailesh,Bhavsar, Dhairya,Shah, Anamik,Coutinho, Evans
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p. 375 - 387
(2014/02/14)
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- A simple synthesis of 4-aroyl-5-methyl-1H-imidazol-2(3H)-one derivatives (Enoxymone analogues) from aryl methyl ketones via enaminones
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Aryl methyl ketones 1a-e gave with N,N-dimethylacetamide dimethylacetal (DMADMA) (E)-1- aryl-3-(dimethylamino)-but-2-en-1-ones 2a-e. Substitution of the N,N-(dimethylamino) group in the reaction with ammonium acetate afforded the corresponding (Z)-3-amino-1-aryl-but-2-en-1- ones 3a-e. In the reaction of 3a-e with diethyl azodicarboxylate intermediates 4a-e were formed, which were, in most cases without isolation, cyclized into ethyl (5-aroyl-4-methyl-2-oxo-2,3- dihydro-1H-imidazol-1-yl)carbamates 5a-e. Hydrolysis of the ester group, followed by the decarboxylation and deamination of intermediates 6a-c,e produced 4-aroyl-5-methyl-1Himidazol- 2(3H)-ones 7a-c,e.
- Bezensek, Jure,Groselj, Uros,Stare, Katarina,Svete, Jurij,Stanovnik, Branko
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p. 294 - 307
(2014/03/21)
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- C^C* cyclometalated platinum(II) NHC complexes with β-ketoimine ligands
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C^C* cyclometalated platinum(II) NHC complexes with chelating acetylacetonate ligands have been recently shown to be an interesting class of phosphorescent emitters. We sought to clarify the role of the acetylacetonate ligand by replacing one of the coord
- Tronnier, Alexander,Poethig, Alexander,Herdtweck, Eberhardt,Strassner, Thomas
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p. 898 - 908
(2014/03/21)
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- Phosphorescent C^C? cyclometalated PtII dibenzofuranyl-NHC complexes - An auxiliary ligand study
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Neutral C^C? cyclometalated PtII NHC complexes have recently emerged as a new class of phosphorescent emitters with high quantum efficiencies, short decay lifetimes and high thermal stability, which makes them promising candidates for OLED applications. Herein, we report investigations on the photophysical properties of seven new PtII complexes containing a chelating NHC dibenzofuranyl ligand (3-methyl-1-dibenzo[b,d]furan-4-ylimidazole) and a bidentate monoanionic auxiliary ligand. All complexes have been fully characterized including extensive NMR studies (COSY, HSQC, HMBC, NOESY, 195Pt NMR), three of them also by solid-state structures. The extraordinary influence of the auxiliary ligands on the photoluminescence properties is demonstrated by quantum yields ranging from 0 % to 91 % in amorphous PMMA films at room temperature. DFT calculations were performed in order to investigate the nature of the emissive states in more detail. Seven new C^C? cyclometalated platinum(II) NHC complexes were synthesized. Three were investigated by X-ray diffraction experiments, and the photoluminescence properties for all were determined. The cyclometalating carbene ligands, with a dibenzofuranyl moiety, were used in combination with different co-ligands. The importance of the right choice of these often underestimated auxiliary ligands becomes obvious when considering the quantum yields, ranging from 0 to 91 %.
- Tronnier, Alexander,Nischan, Nicole,Metz, Stefan,Wagenblast, Gerhard,Münster, Ingo,Strassner, Thomas
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p. 256 - 264
(2015/04/27)
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- Syntheses of mixed chelate copper(II) complexes containing β-ketoaminato and diamine ligands: Solvatochromism study
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Three new mixed-chelate Cu(II) complexes incorporating N,N,N′, N′-tetramethylenediamine (tmen) or N,N-dimethyl,N′-benzyl- ethylenediamine (dmben) as diamine chelate and a β-ketoaminato such as 4-amino-3-penten-2-onato (APO) or 3-amino-3-phenyl-2-buten-1-onato (APBO) with the general formula [Cu(β-ketoamine)(diamine)]ClO4 were prepared and characterized. Their solvatochromic properties were studied by visible spectroscopy. X-ray crystal analysis confirmed that copper (II) ion in [Cu(APO)(tmen)]ClO4 and[Cu(APBO)(tmen)]ClO4 is almost in a square planar environment. Structure of [Cu(APO)(dmben)]ClO4 was investigated by DFT calculation. The solvent-dependent visible spectroscopic absorption maxima, νmax, were analyzed using stepwise multiple linear regression (SMLR) method to find the best model explaining the observed positive solvatochromism. The analysis demonstrated that among different solvent parameters, donor number (DN) is a dominant factor responsible for the shift in the d-d absorption band of the complexes to the lower wavenumber with increasing its values. The importance of steric effect in the diamine ligand and more delocalization of pi-bands in the β-ketoamine on the spectral and SMLR measurements are discussed.
- Golchoubian, Hamid,Rezaee, Ehsan,Bruno, Giuseppeh,Rudbari, Hadi Amiri
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- Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles
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A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.
- Liu, Xin,Cheng, Ran,Zhao, Feifei,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
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supporting information
p. 5480 - 5483,4
(2012/12/12)
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- Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles
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A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.
- Liu, Xin,Cheng, Ran,Zhao, Feifei,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
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supporting information
p. 5480 - 5483
(2013/01/15)
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- Solid-state synthesis of β-enamino ketones from solid 1,3-dicarbonyl compounds and ammonium salts or amines
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A facile amination of solid 1,3-dicarbonyl compounds with ammonium salts or amines in solid state has been achieved by mechanochemical grinding in the presence of KHSO4 and SiO2. Most of the reactions proceed smoothly at room temperature under solid-state conditions and give their corresponding β-imino derivatives in high yields. The method has the advantage of simple manipulation and mild conditions. Georg Thieme Verlag Stuttgart.
- Xu, Shi-Liang,Li, Cheng-Ping,Li, Jing-Hua
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experimental part
p. 818 - 822
(2009/07/18)
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- Asymmetric synthesis of 4H-1,3-oxazines: Enantioselective reductive cyclization of N-acylated β-amino enones with trichlorosilane catalyzed by chiral Lewis bases
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N-Acylated β-amino enones reductively cyclize by treatment with trichlorosilane and a chiral Lewis base catalyst to afford optically active 4H-1,3-oxazines, which can be transformed to other chiral compounds without racemization.
- Sugiura, Masaharu,Kumahara, Mako,Nakajima, Makoto
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supporting information; experimental part
p. 3585 - 3587
(2009/12/03)
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- NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS
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The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.
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Page/Page column 43-44; 65; 112; 246
(2010/11/28)
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- Ionic liquid promoted simple and efficient synthesis of β-enamino esters and β-enaminones from 1,3-dicarbonyl compounds - One-pot, three-component reaction for the synthesis of substituted pyridines
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A facile enamination of 1,3-dicarbonyl compounds with amines has been developed that affords good to excellent yields of β-enamino esters and β-enaminones using Bronsted acidic ionic liquid 1-methylimidazolium trifluoroacetate ([Hmim]+Tfa-) at room temperature. This methodology has been extended for the synthesis of substituted pyridines in excellent yield by a one-pot, three-component reaction of 1,3-dicarbonyl compounds, ammonium acetate, and alkynone in the presence of [Hmim] +Tfa-.
- Karthikeyan, Ganesan,Perumal, Paramasivan T.
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p. 1746 - 1751
(2007/10/03)
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- Solution and solid state structure and tautomerism of azo coupled enaminone derivatives of benzoylacetone
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The reaction of 4-substituted benzenediazonium tetrafluoroborates with 3-amino-1-phenylbut-2-en-1-one, 4-amino-4-phenylbut-3-en-2-one and their N-aryl derivatives 1a-1g has been used to prepare the respective azo coupling products i.e. compounds 2-5 from
- Simunek, Petr,Bertolasi, Valerio,Peskova, Marketa,Machacek, Vladimir,Lycka, Antonin
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p. 1217 - 1226
(2007/10/03)
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- A new and a convenient route to enaminones and pyrazoles
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A new method has been developed for the regioselective preparation of enaminones and pyrazoles from 1,3-diketonatoboron difluorides. The reactions proceed smoothly under mild reaction conditions, producing enaminones and pyrazoles in high yields.
- Stefane, Bogdan,Polanc, Slovenko
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- Synthesis of silylated β-enaminones and applications to the synthesis of silyl heterocycles
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Silyl β-enaminones have been synthesized by reductive cleavage of silylisoxazoles. These versatile synthons bearing the silyl group in different positions of the enamino ketonic system are of great interest in the construction of a variety of penta- and hexaheterocycles, which, in general, retain the silyl group attached at the ring or in a side chain.
- Calvo, Luis A.,González-Nogal, Ana M.,González-Ortega, Alfonso,Sa?udo
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p. 8981 - 8984
(2007/10/03)
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- The use of K-10/ultrasound in the selective synthesis of unsymmetrical β-enamino ketones
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p-Phenyl substituted β-enamino ketones 2a-p and cyclic β-enamino ketones 4, 6a-f have been prepared by a selective method by dispersing 1,3- diketones and amines on montmorillonite K-10 under sonication.
- Valduga, Claudete J.,Squizani, Adriana,Braibante, Hugo S.,Braibante, Mara E.F.
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p. 1019 - 1022
(2007/10/03)
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- Stereocontrolled conversion of 3-unsubstituted isoxazole compounds into Z-β-siloxyacrylonitriles. A new method for the regioselective synthesis of β-enaminoketones
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The stereoselective synthesis of Z-β-siloxyacrylonitriles via base-induced ring cleavage of isoxazole precursors is described. Z-β-siloxyacrylonitriles react with organolithium compounds to give high yields of β-enaminoketones 1.
- Gonzalez,Gonzalez,Pulido
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p. 1005 - 1014
(2007/10/02)
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- Thermochemical and Crystallographic Studies of some β-Ketoimine Derivatives
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The standard (po = 0.1 MPa) molar enthalpies of formation at 298.15 K in the gaseous state of some β-ketoimines, RCOCH=C(CH3)NMR1, were determined from their enthalpies of combustion and of sublimation, ΔfHmsup
- Silva, Manuel A. V. Ribeiro Da,Silva, Maria D. M. C. Ribeiro Da,Paiva, Jose P. A.,Nogueira, Isabel M. C. S.,Damas, A. Margarida,et al.
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p. 1765 - 1770
(2007/10/02)
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- PREPARATION OF NEW ORGANIC LUMINOPHORES BASED ON 3,5-DIACETYLPYRIDINES
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The reaction of acetylacetone or sodium salt of oxymethyleneacetone with corresponding aldehydes has been used to prepare 3,5-diacetyl-1,4-dihydropyridines III which have been oxidized to diacetylpyridines VII.These compounds have been transformed by an acid-catalyzed reaction with benzaldehyde into the chalcones VIII which have been utilized for the Kroehnke synthesis of luminophoric terpyridines I and II.
- Lhotak, Pavel,Kurfuerst, Antonin
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p. 1937 - 1946
(2007/10/02)
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- A Facile and Novel Synthesis of 1,6-Naphthyridin-2(1H)-ones
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A new and convenient procedure for the synthesis of 1,6-naphthyridin-2(1H)-ones and their derivatives is described.In the first scheme 5-acetyl-6--1,2-dihydro-2-oxo-3-pyridinecarbonitrile (4) obtained by the reaction of N,N-dimet
- Singh, Baldev,Lesher, George Y.
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p. 2085 - 2091
(2007/10/02)
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- Lactam Acetals: Part XVI-A New and Convenient Synthesis of 4-Substituted 1-Alkyl-6-methyl-2,3-dihydropyrrolo-pyridines
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Reaction of 2,2-dimethoxy-1-alkylpyrrolidines (1) and (2) with enaminones 3 and 4 results in the formation of 4-substituted-1-alkyl-6-methyl-2,3-dihydropyrrolopyridines (5-7).
- Jotwani, Padma,Singh, Jujhar,Anand, Nitya
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