- Simple synthesis, structure and ab initio study of 1,4-benzodiazepine-2,5- diones
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A simple procedure for the synthesis of pyrido[2,1-c][1,4] benzodiazepine-6,12-dione (1) and 1,4-benzodiazepine-2,5-diones (2a-2d), using microwave irradiation and/or conventional heating is reported. The configuration of 1 was determined by single-crysta
- Jadidi, Khosrow,Aryan, Reza,Mehrdad, Morteza,Lügger, Thomas,Ekkehardt Hahn,Ng, Seik Weng
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- A novel one step approach to the synthesis of 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones from 1,2,3-benzotriazin-4-(3H)-one
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1,2,3-Benzotriazin-4-(3H)-one(3) and its 6-chloro derivative (4) on thermal condensation with α-amino acids yielded 3H-1,4-benzodiazepin-(1H,4H)-2,5-diones(7-12) in moderate to good yield. The cyclocondensation is believed to proceed through the formation of an iminoketene intermediate (5).
- Gupta, Renu,Sirohi, Reenu,Shastri, Sudha,Kishore
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p. 363 - 366
(2007/10/03)
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- Solid phase synthesis of 1,4-benzodiazepine-2,5-diones
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1,4-benzodiazepine-2,5-diones were synthesized by a simple procedure utilizing polymer supported amino acids and o-nitrobenzoic acids or protected anthranilic acids. Cyclization of the common aminoamide intermediate with concomitant release from the support furnished the desired 1,4-benzodiazepine-2,5-diones. The products were recovered in high yields and exhibited excellent purities.
- Mayer, John P.,Zhang, Jingwen,Bjergarde, Kirsten,Lenz, Doug M.,Gaudino, John J.
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p. 8081 - 8084
(2007/10/03)
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- New routes to 1,4-benzodiazepin-2,5-diones
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1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.
- Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont
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p. 9051 - 9060
(2007/10/02)
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- New synthesis of 1,4 benzodiazepine-2,5-diones by means of HCl gas catalyst
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A new synthesis of 1,4-benzodiazepinediones 4, particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptide 12, was achieved by action of dry HCl gas in DM
- Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont
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p. 2265 - 2272
(2007/10/02)
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- A Versatile Synthesis of 3H-1(H),4(H)-Benzodiazepin-2,5-diones
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Reaction of isatoic anhydrides (1) and α-amino acids (2) in glacial acetic acid under reflux gave 3H-1(H),4(H)-benzodiazepin-2,5-diones (3) in good yields.These compounds have been characterised by UV, IR, mass, PMR and 13C-NMR spectra.
- Mohiuddin, G.,Reddy, P. S. N.,Ahmed, Khalil,Ratnam, C. V.
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p. 905 - 907
(2007/10/02)
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