- A Novel compound
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The present invention relates to a novel compound and uses thereof. The novel compound according to the present invention, by inducing the activation of an MKP-1 protein, has an effect of inhibiting inflammatory responses very effectively that occur in respiratory diseases by blocking cell signaling in the order of p38/CK2alpha/NF-kappaB. Accordingly, it is possible to prevent, alleviate or treat the respiratory diseases by oral administration of the novel compound of the present invention.
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Paragraph 0072-0073; 0087-0088; 0106-0108; 0146-0148
(2021/06/15)
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- GLUTAMINASE INHIBITORS
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Disclosed are newly identified chemotherapeutic agents. These inhibitors are particularly useful in the treatment of cancers such as leukemic cells and pancreatic cancers.
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Paragraph 0105
(2019/10/20)
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- Substituted 2-(2, 6-Dioxopiperidin-3-yl)-1-method of preparing oxoisoindolines
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The present invention concerns new processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines which are useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF±. The i
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Paragraph 0080
(2018/11/22)
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- An access to aza-Freidinger lactams and E-locked analogs
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Freidinger lactams, possessing a peptide bond configuration locked to Z, are important key elements of conformationally restricted peptidomimetics. In the present work, the CαHi+1 unit has been replaced by N, leading to novel aza-Fre
- Ottersbach, Philipp A.,Schmitz, Janina,Schnakenburg, Gregor,Gütschow, Michael
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supporting information
p. 448 - 451
(2013/04/11)
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- Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles
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Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.
- Woodard, Scott S.,Jerome, Kevin D.
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experimental part
p. 132 - 137
(2012/04/18)
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- Synthesis of imidazolidin-2-one-4-carboxylate and of (tetrahydro)pyrimidin- 2-one-5-carboxylate via an efficient modification of the Hofmann rearrangement
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A mild and efficient methodology for the rearrangement of protected asparagine and protected glutamine is reported; good results are obtained with a wide selection of protecting groups. The Royal Society of Chemistry.
- Angelici, Gaetano,Contaldi, Simone,Lynn Green, Sarah,Tomasini, Claudia
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experimental part
p. 1849 - 1852
(2008/10/09)
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- Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
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The structure of sulphostin (1), a novel dipeptidyl peptidase IV (DPP-IV) inhibitor, is consisted of three key functional groups, including a characteristic amino(sulfoamino)phosphinyl group, on a piperidine ring. To examine the relationship between its s
- Abe, Masatoshi,Akiyama, Tetsuo,Umezawa, Yoji,Yamamoto, Keiichiro,Nagai, Masashi,Yamazaki, Hiroko,Ichikawa, Yuh-Ichiro,Muraoka, Yasuhiko
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p. 785 - 797
(2007/10/03)
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- Utility of tetrathiomolybdate and tetraselenotungstate: Efficient synthesis of cystine, selenocystine, and their higher homologues
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Efficient synthesis of cystine, selenocystine, and their higher homologues like homo and bishomo amino acid derivatives from natural amino acid derivatives using tetrathiomolybdate and tetraselenotungstate reagents under mild and neutral conditions is reported. The generality of the reaction has been studied by capping various groups to amino and carboxyl components of canonical amino acids.
- Bhat, Ramakrishna G.,Porhiel, Emmanuel,Saravanan, Vadivelu,Chandrasekaran, Srinivasan
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p. 5251 - 5253
(2007/10/03)
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- A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates
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A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.
- Reddy, Dandu R,Iqbal, Mohamed A,Hudkins, Robert L,Messina-McLaughlin, Patricia A,Mallamo, John P
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p. 8063 - 8066
(2007/10/03)
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- New reaction conditions using trifluoroethanol for the E-I Hofmann rearrangement
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The Hofmann rearrangement of -protected glutamine esters to N2-protected (2S)-4-[(2,2,2-trifluoroethoxy)carbonyIamino]-2-aminobutyric acid esters was successfully achieved by an electrochemical method using a trifluoroethanol (TFE)-MeCN solvent system where the TFE may play an important role in controlling the basicity caused by electrochemically generated bases.
- Matsumura, Yoshihiro,Yuki Satoh, Kimihiro Shirai,Onomura, Osamu,Toshihide, Maki
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p. 2057 - 2060
(2007/10/03)
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- 'BOP' as a reagent for mild and efficient preparation of esters
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A simple procedure for preparation of esters under mild conditions employing the BOP reagent is reported. Acid and base labile protecting groups commonly used with amino acids e.g. t-butyl, Fmoc etc., are well tolerated under these conditions. The mechani
- Kim,Patel
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p. 5603 - 5606
(2007/10/02)
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