- Studies with functionally substituted enamines: The reactivity of enaminals and enamino esters toward naphthoquinone, hydrazonoyl halides, aminoazoles and hippuric acid
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Whereas enamines 1a,b react with naphthoquinone (2) to yield the naphthofuranals 5a,b, enamine ester 1c react with 2 to yield benzoindole derivatives 7. Enamine 1b reacts with hydrazonoyl halides 8 to yield 3,4-disubstituted pyrazoles 12. On the other hand, the enaminal 1a failed to react with 8, while enamine ester 1c afforded hydrazone 16 on treatment with 8. The enamino ester 1b afforded triethyl 1,3,5-benzenetricarboxylates on refluxing in acetic acid. Georg Thieme Verlag Stuttgart.
- Al-Saleh, Balkis,Makhseed, Saad,Hassaneen, Huwaida M. E.,Elnagdi, Mohamed Hilmy
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- 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS
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The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.
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(2010/04/03)
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- N- and O-substituted aminophenols, method and use for diagnosis
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The present invention provides N- and O-substituted aminophenol derivatives of the general formula STR1 wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolyses, as well as for the preparation of agents for carrying out determinations of hydrolyses.
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