- Preparation method of ultraviolet absorbent 2-phenyl benzimidazole (by machine translation)
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The crude product 2 - obtained by the sulfonation reaction, is prepared by adding :S1: phenyl benzimidazole 2 - organic solvent, into a reaction vessel and then adding an active carbon stirring decolorizing, to fully react, to obtain ;S2:phenyl benzimidazole - 5 5-sulfonic acid crude S1 by stirring, and then adding an active carbon to remove, out of solid, after solid-liquid separation, and solid 2 - is obtained, by solid-liquid separation.S3: The product obtained by the preparation method S2 of the invention is obtained by stirring, decoloring, decoloring, decoloring and decoloring with an active carbon stirring, decolorizing layer, and then, adding an, active carbon to, prepare a crude 2 - white product (PH,) by. solid-liquid separation (step 2 -) and, solid-liquid separation, (, g,) of the product obtained, by the preparation method of, the present application, and stirring and decolorizing the crude product by stirring and decolorizing the crude product. (by machine translation)
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Paragraph 0027-0046
(2020/05/01)
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- Preparation method of ultraviolet absorber 2-phenylbenzimidazole-5-sulfonic acid
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The invention relates to a preparation method of an ultraviolet light absorber 2-phenylbenzimidazole-5-sulfonic acid. The method specifically comprises the following steps: S1, adding 2-phenylbenzimidazole and an organic solvent into a reaction vessel, adding a composite sulfonating agent while stirring, and sufficiently making a reaction; S2, performing standing and layering on a product obtainedby sulfonation reaction in the S1, stirring and quenching a lower-layer solution, separating out a solid, and carrying out solid-liquid separation to obtain a 2-phenylbenzimidazole-5-sulfonic acid crude product; and recycling and reusing the organic solvent on the upper layer; and S3, putting the crude product obtained in the S2 into water, adjusting the pH value while stirring to fully dissolvethe 2-phenylbenzimidazole-5-sulfonic acid crude product, adding activated carbon, performing stirring for decolorization, performing filtering, adding acid into the filtered clarified solution for acidification, separating out solids, carrying out solid-liquid separation, and performing drying to obtain a 2-phenylbenzimidazole-5-sulfonic acid refined product. By the adoption of the preparation method, the obtained product is high in purity and good in quality; meanwhile, the waste acid generation amount is small, a pure white product can be obtained through one-time refining, and the process is simplified.
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Paragraph 0027-0048
(2020/07/13)
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- Method for preparing sulfo-substituted benzimidazole and derivatives thereof
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The invention discloses a preparation method for sulfo-substituted benzimidazole and derivatives thereof. The preparation method comprises the following steps: with organic carboxylic acid A and o-phenylenediamine as raw materials, carrying out a reflux reaction to generate a benzimidazole compound B; and reacting the benzimidazole compound B with a sulfonating agent to prepare the sulfo-substituted benzimidazole compound C. The yield and the content of the intermediate benzimidazole compound B are effectively improved by means of controlling the dosage ratio of raw materials, selecting a proper catalyst, inhibiting the oxidation of o-phenylenediamine and the like in the dehydration and cyclization process of carboxyl-amido groups; in the process of a sulfonation reaction, reaction temperature is reduced, the content and yield of the target products are obviously improved, and the generation of isomers is inhibited by controlling the addition manner of the raw materials and selecting aspecific catalyst. Meanwhile, the reaction conditions and operation of all the steps are simple, and the method is easy to control and convenient for realization of industrial production.
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Paragraph 0098-0111; 0117-0120; 0124-0127
(2019/12/25)
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- Synthesis, crystal structure and properties of 2-phenyl-1H-benzo[d]imidazole-5-sulfonic acid
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A new UV absorber, 2-phenyl-1H-benzo[d]imidazole-5-sulfonic acid (Pbsa), was synthesized, and structurally characterized by single-crystal X-ray diffraction, elemental analysis, IR spectrum, 1H and 13C nuclear magnetic resonance. The product crystallizes in monoclinic system, space group P21/n with a = 9.9475(14), b = 8.8269(12), c = 16.459(2) ?, β = 100.620(2)°, V = 1420.4(3) ?3, Z = 4, and Rgt(F) = 0.0513, wRref(F2) = 0.1264. The UV-Vis absorption in the region of 290 and 360 nm is attributed to the conjugated system. The result of biochemical tests can show that Pbsa is not toxic and cannot damage the liver, renal, pancreatic, and ion metabolism functions of the experimental mice through skin and wounds. It can be used for skin sunscreen without acute skin toxicity. It shows the good photostability, which can be comparable to that of commercially available UV absorber, UV1577.
- Guan, Lei,Luo, Guanhua,Wang, Ying
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p. 345 - 350
(2018/09/29)
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- NEW DUALISTIC MOLECULES HAVING UV RADIATION FILTRATING ABILITY AT WIDE SPECTRUM AND POTENT DAMPING ACTIVITY OF THE REACTIVITY OF FREE RADICALS (RADICALS SCAVENGING)
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Compound with structure 2-phenylbenzimidazole of formula I and/or a pharmaceutically acceptable salt thereof, wherein said compound of formula I corresponds to: in which n is 1, 2 or 3 and in which R is a carboxyl radical (-COOH) or a sulphonic radical (-S03H); pharmaceutical and/or cosmetic formulation and/or medical device comprising such a compound; method for synthesising it.
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Page/Page column 35
(2013/07/19)
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- Trimethylsilyl chloride catalyzed synthesis of substituted benzimidazoles using two phase system under microwave conditions, and their antimicrobial studies
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A convenient method using TMSCl (20 mol%) and microwave-induced technique for the synthesis of various benzimidazole is described. This has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Preliminary results indicated that, compounds 3e, 3f, 3g, 3k, 3m, 3n and 3o demonstrated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds have exhibited activity at MIC of 6.25 μg/mL.
- Karuvalam, Ranjith P.,Haridas, Karickal R.,Shetty, Suchetha N.
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p. 1122 - 1125,4
(2020/08/24)
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- COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
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The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group FA which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group FC capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group FA.
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- Tetra butyl ammonium chloride catalyzed synthesis of substituted benzimidazoles under microwave conditions
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TBACl (10 mol %) was found to be a useful catalyst for the synthesis of substituted benzimidazoles. The method was proved to be simple, convenient and the product was isolated with good yield.
- Ranjith, P. Karuvalam,Siji,Divia,Karickal, R. Haridas
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experimental part
p. 589 - 593
(2011/01/12)
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- Cosmetic compositions comprising photostabilized dibenzoylmethane compounds and 2-pyrrolidinone-4- carboxy esters
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Photostable cosmetic compositions contain, formulated into a cosmetically acceptable vehicle, at least one UV-screening system that includes: (a) at least one dibenzoylmethane compound, and(b) at least one 2-pyrrolidinone-4-carboxy ester compound having the following formula (I): in which: R1 is a linear or branched C1-C20 alkyl radical, andR2 is a linear or branched C1-C20 alkyl radical which optionally includes a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical.
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- OIL-IN-WATER EMULSION
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The present invention relates to a composition in the form of an emulsion of the oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and which are dispersed in an aqueous phase, wherein it has a pH ranging from 3 to 5.5 and in that it contains at least one lipophilic surface-active agent with an HLB ranging from 2 to 5, at least one hydrophilic surface-active agent with an HLB ranging from 8 to 12 and at least one amphiphilic compound of ionic nature at a pH ranging from 3 to 5.5.
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- Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
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Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.
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- Use of Mineral/Organic Composite Material in the Form of an Ultraviolet Radiation Protective Agent
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The invention relates to the use of composite material which comprises nanoparticles of a least one metal derivative and at least one organic sunscreen agent which is chemically bound with said particles in a covalent manner in the form of an ultraviolet radiation protective agent containing the inventive composite material. Cosmetic ultraviolet radiation protective compositions comprises said mixture are also disclosed.
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- COSMETIC OIL-IN-WATER EMULSION
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A cosmetic or dermatological compositions of oil-in-water emulsion type, including, in a physiologically acceptable medium, at least gemini surfactant of formula (I): in which R1 and R3 denote, independently of one another, an alkyl radical containing from 1 to 25 carbon atoms; R2 denotes a spacer consisting of a linear or branched alkylene chain containing from 1 to 12 carbon atoms; X and Y denote, independently of one another, a group —(C2H4O)a—(C3H6O)bZ; n ranges from 1 to 10, in combination with an effective amount of at least one semi-crystalline polymer which is solid at ambient temperature and which has a melting point below 70° C., said polymer having a number-average molecular mass greater than or equal to 2000, said emulsion having a proportion of fatty phase of greater than 10% by weight relative to the total weight of the composition and including more than 40% by weight of non-volatile oil(s) relative to the weight of the fatty phase.
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- Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and siloxane-containing arylalkyl benzoate amide compounds
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Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane sunscreen compound and at least one photostabilizing siloxane-containing arylalkyl amide compound of formula (I) below:
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- Photostabilized dibenzoylmethane sunscreens immobilized within sol/gel matrices
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Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of the skin, hair, nails, eyebrows, eyelashes and/or lips, contain an effective photostable and UV-photoprotecting amount of at least one dibenzoylmethane organic sunscreen immobilized within a matrix prepared via sol-gel process from at least one silicon alkoxide, at least one non-ionic surfactant and water, but in the absence of any organic solvent, formulated into a topically applicable, cosmetically/dermatologically acceptable medium therefor.
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- Finely divided photoprotective oil-in-water emulsions comprising 4,4-diarylbutadiene UV-A sunscreens
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UV-Photoprotective oil-in-water emulsions well suited for photoprotecting the skin, lips and/or hair against the damaging effects of UV-radiation, the oil globules of which having an average size of at most 500 nm and containing particles of at least one ionic polymer and at least one UV-radiation-screening system, such screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent.
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- Aqueous photoprotective compositions comprising acrylamido-2-methylpropanesulfonic acid polymers and 4,4-diarylbutadiene UV-A sunscreens
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Photoprotective compositions, e.g., oil-in-water or water-in-oil emulsions, well suited for the photoprotection of the skin, lips and/or hair against the damaging effects of UV-radiation, comprise at least one aqueous phase, at least one oily phase, at least one partially or completely neutralized, crosslinked or non-crosslinked water-soluble or water-dispersible acrylamido-2-methylpropanesulfonic acid (AMPS) polymer and at least one UV radiation-screening system, said at least one screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent
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- SYNERGISTICALLY UV-PHOTOPROTECTING MIXED SUNSCREEN COMPOSITIONS
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Topically applicable cosmetic/dermatological sunscreen composition well suited for the enhanced UV-photoprotection of human skin and/or hair, contain synergistically UV-APPD-enhancing amounts of (i) at least one UV-screening silicon compound having a benzotriazole functional group substituent, (ii) at least one UV-screening dibenzoylmethane compound, and (iii) at least one UV-screening amino-substituted 2-hydroxybenzophenone compound having the following structural formula (III): formulated into (iv) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.
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- Synergistically UV-photoprotecting sunscreen compositions comprising camphorsulfonic acid/benzophenone compounds
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Topically applicable cosmetic/dermatological sunscreen compositions well suited for the enhanced UV-photoprotection of human skin and/or hair, contain synergistically SPF-enhancing amounts of (a) benzene-1,4-di(3-methylidene-10-camphorsulfonic acid), optionally in partially or completely neutralized state, and (b) at least one amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I): formulated into (c) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.
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- Structure-improving hair care agents
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There are provided topical hair care compositions for improving the structure and strength of hair keratin and the fastness to washing of hair colors which contain vitamin B6 derivatives of the formula (1) or physiologically compatible salts thereof.
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- STABLE/IMPROVEDLY SELF-TANNING COMPOSITIONS COMPRISING AMINO-SUBSTITUTED 2-HYDROXYBENZOPHENONE COMPOUNDS
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Topically applicable cosmetic/dermatological self-tanning compositions well suited for enhancing the coloration imparted by and/or the stabilizing of the self-tanning agent, contain (i) an effective amount of at least one artificial/sunless tanning agent, and (ii) an effective stabilizing/enhancedly self-tanning amount of at least one amino-substituted 2-hydroxybenzophenone compound having the following structural formula (I): formulated into (iii) a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.
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- Cosmetic skin-care product against ageing of the skin as an effect of light
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The present invention relates to a new cosmetic skin-care product for external use, which is based on UV-radiation-absorbing substances in combination with a free-radical scavenger system.
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- Cosmetic composition with photoprotective properties
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The invention is directed to a cosmetic composition with synergistically improved photoprotective properties, comprising at least one component selected from the group of Vitamin E, Vitamin C, derivatives of Vitamin E, derivatives of Vitamin C, and combinations of at least two of these components, and at least one natural polyamine or derivative.
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- Self-tanning cosmetic compositions containing dihydroxyacetone
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There is disclosed an artificial tanning composition, preferably in the form of a gel, comprising a cosmetically effective amount of dihydroxyacetone (DHA) as an artificial tanning agent, an alcoholic phase and a hydroxypropylcellulose thickener. The composition may further comprise a glycol, preferably selected from one or more of ethoxydiglycol, propylene glycol and butylene glycol. The composition may further comprise ingredients miscible with oil. Preferably the composition is substantially transparent to visible light, and may further comprise a colouring agent, which is preferably oil soluble, to tint the composition. There is also disclosed a method of preparing artificial tanning compositions comprising the steps of: a) dissolving dihydroxyacetone in a minimum amount of water, b) adding alcohol to the aqueous solution from step a), c) dispersing hydroxypropylcellulose in the alcoholic mixture from step b), d) optionally, heating and then cooling to ambient temperature any remaining ingredients; and e) optionally, adding the remaining ingredients treated as in step d) to the alcoholic mixture from step c).
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- Process for preparing 2-arylbenzimidazole-5-sulfonic acids
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The invention relates to an improved process for preparing 2-arylbenzimidazole-5-sulfonic acids of the formula I, STR1 in which Ar is unsubstituted phenyl or phenyl substituted by one or more C1 -C6 alkyl or alkoxy groups and m is 1, 2 or 3, wherein o-phenylenediamine is reacted in the presence of sulfuric acid at between room temperature and 250° C. with a benzoic acid derivative of the formula II in which Ar and m are as above, and X is COO-alkyl, where alkyl is n-alkyl having from 1 to 6 C atoms, COOH, COCl, COBr or CN, and new arylbenzimidazole acids of the formula Ia STR2
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- Cosmetic sunscreen
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The present invention relates to a new cosmetic sunscreen in emulsion form for external application, based on absorbent and reflecting substances in combination with a new radical scavenger system, and to a process for its preparation.
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