- A suitable for industrial production process for the separation of chemical synthesis salidroside
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The invention discloses a separation method suitable for chemical synthesis of salidroside for industrial production. The method comprises the following steps: carrying out a reaction on Beta-D-pent-acetyl glucose and hydroxyphenethyl alcohol under the catalytic action of a lewis acid; and carrying out deacetylation on a generated tetraacetyl salidroside product so as to prepare the salidroside. Thus, the salidroside product is synthesized in a separating manner via an extraction and recrystallization method while a simple and convenient synthesis method is adopted at the same time. Compared with the traditional chemical synthesis process, the method disclosed by the invention is low in cost, high in yield, short in reaction time, simple and simple, convenient and environmentally friendly in synthesis process, thereby being suitable for industrial production, and the raw materials are easily available.
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Paragraph 0024-0026; 0030-0032; 0035-0037; 0040-0042
(2019/02/04)
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- Development of a kilogram-scale synthesis of salidroside and its analogs
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An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The process consists of two chemical steps, which produce the salidroside on a multikilogram scale with 72% overall yield and >98% purity.A series of novel salidroside analogs were prepared according to the same method. Taylor & Francis Group, LLC.
- Shi, Tianyao,Chen, Hui,Jing, Linlin,Liu, Xueying,Sun, Xiaoli,Jiang, Ru
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experimental part
p. 2594 - 2600
(2011/08/07)
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- Synthesis of 13C-labeled possible intermediates in the biosynthesis of phenylethanoid derivatives, cornoside and rengyosides
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In order to clarify the biosynthetic pathway of C6-C2 unit compounds containing salidroside, cornoside, and rengyosides A and B in oleaceous plants, 13C-labeled putative precursors, 4-hydroxyphenylethanol, salidroside and cornoside, were prepared.
- Kuwajima, Hiroshi,Takai, Yoshitaka,Takaishi, Kiyokazu,Inoue, Kenichiro
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p. 581 - 586
(2007/10/03)
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- BIOGENESIS-LIKE TRANSFORMATION OF SALIDROSIDE TO RENGYOL AND ITS RELATED CYCLOHEXYLETANOIDS OF FORSYTHIA SUSPENSA
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Photooxygenation of salidroside (8) in methanol in presence of Rose Bengal afforded cornoside (9), which, on high pressure hydrogenation with 5percent palladium on activated carbon, yielded rengyoside B (6).Reduction of 6 with sodium borohydride gave rengyoside A(5) stereoselectively.By enzymatic hydrolysis, 9, 6 and 5 furnished rengyolone (4), rengyoxide (3) and rengyol (1), respectively. Similerly, p-hydroxyphenylethanol (10), the aglycone part of salidroside (8), was oxygenated photochemically to a dienone alcohol, which cyclized spontaneously to rengyolone (4).Hallerone (17) was obtained by the photooxygenation of p-hydroxyphenylethyl acetate (10b).Thus the plausible biosynthetic routes from salidroside (8) to rengyol (1) and the related natural cyclohexylethanoids were simulated chemically.
- Endo, Katsuya,Seya, Kazuhiko,Hikino, Hiroshi
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p. 3673 - 3682
(2007/10/02)
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- Aryl β-d-glucosides from Carica papaya fruit
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Benzyl β-d-glucoside, 2-phenylethyl β-d-glucoside, 4-hydroxyphenyl-2-ethyl β-d-glucoside and four isomeric malonated benzyl β-d.
- Schwab, Wilfried,Schreier, Peter
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p. 1813 - 1816
(2007/10/02)
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