Synthetic Studies for Novel Structure of α-Nitrogenously Functionalized α-Fluorocarboxylic Acids. Part 1. The First Synthesis and Reactions of N-Protected α-Fluoroglycines
The first synthesis of the N-protected α-fluoro-α-amino acid esters 12, 13, 21 and 22, and the corresponding acids 16 and 24, is described.Reaction of ethyl and t-butyl bromofluoroacetates 4 and 9 with di-t-butyl and dibenzyl iminodicarboxylate potassium