- Fluorodenitration of activated diphenyl sulphones using tetramethylammonium fluoride
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Fluorodenitration of nitro-substituted diphenyl sulphones occurs readily in dipolar aprotic solvents using tetramethylammonium fluoride as the source of fluoride, although other reactions including fluorodesulphonylation can sometimes occur in competition. - Keywords: Fluorodenitration; Diphenyl sulphones; Tetramethylammonium fluoride; NMR spectroscopy; Mass spectrometry
- Clark, James H.,Wails, David
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p. 201 - 206
(2007/10/02)
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- Isomerisation Accompanying Fluorodenitration of Trifluoromethyl Activated Diphenyl Sulfones
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Fluorodenitration of 2-(4-chlorobenzene sulfonyl)-5-nitrobenzotrifluoride using tetramethyl ammonium fluoride affords a mixture of 2-fluoro-5-nitrobenzotrifluoride and two isomers of (4-chlorobenzene sulfonyl)-fluorobenzotrifluoride.
- Clark, James H.,Wails, David
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p. 3901 - 3902
(2007/10/02)
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- A General Procedure for the Fluorodenitration of Aromatic Substrates
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The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.
- Maggini, Michele,Passudetti, Margherita,Gonzales-Trueba, Guadalupe,Prato, Maurizio,Quintily, Ugo,Scorrano, Gianfranco
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p. 6406 - 6411
(2007/10/02)
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