- Thiourea inhibitors of herpes viruses. Part 1: Bis-(aryl)thiourea inhibitors of CMV
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Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.
- Bloom, Jonathan D.,DiGrandi, Martin J.,Dushin, Russell G.,Curran, Kevin J.,Ross, Adma A.,Norton, Emily B.,Terefenko, Eugene,Jones, Thomas R.,Feld, Boris,Lang, Stanley A.
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p. 2929 - 2932
(2007/10/03)
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- Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors
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Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.
- Tordeux, Marc,Langlois, Bernard,Wakselman, Claude
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p. 2293 - 2299
(2007/10/02)
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- Combating fungi with dicarboxylic acid mono-arylhydrazides
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Combating fungi with dicarboxylic acid mono-aryl-hydrazides of the formula STR1 in which R1 and R2 each independently is hydrogen, halogen, C1 -C4 alkyl, C1 -C4 alkoxy, C1 -C4 alkylmercapto, trihalogenomethyl, trihalogenomethoxy, trihalogenomethylmercapto or nitro, X is an alkylene, alkenylene, cycloalkylene, cycloalkenylene, cycloalkadienylene or phenylene radical, and M is hydrogen or one equivalent of a metal, or a salt thereof.
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- Experimental and quantum chemical study on nano-copper immobilized on magnetic graphitic carbon nitride core shell particles; a reusable heterogeneous catalyst toward reduction of nitro arenes
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A new magnetic material, which named CuFe2O4?SiO2?g-C3N4/Cu with a core/shell morphology has been designed and synthesized. For the first time ever, the mixture of carbon and g-C3N4 layer was applied as an effective linker for immobilization of Cu metal on the catalyst. The physiochemical properties of the catalyst were identified by XRD, FT-IR, VSM, FE-SEM and TEM characterization techniques. The reduction of nitro compounds to the corresponding amines was investigated in the presence of NaBH4 at 55 °C in water. Quantum chemical study reveals that the addition of Cu atoms to the g-C3N4 layer induce a slight structural deformation via changing the bond lengths and bond orders, also the type of interaction of Cu atoms and nitrogen atoms of g-C3N4 is mainly electrostatic in nature. Induced pattern of charge distribution provided by Electrostatic Potential Map exhibits the attractive regions for electrophiles and nucleophiles interacting with this system.
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