The synthesis of F-alkyl and Cl-alkyl monofluoromethyl ketones has been achieved by oxidation of the homologous alcohols under phase-transfer conditions using Na2Cr2O7/H2SO4 in methylene chloride in t
Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes
Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when 18F-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH).
Borz?cka, Wioleta,Lavandera, Iván,Gotor, Vicente
supporting information
p. 5022 - 5025
(2013/09/02)
ORGANIC COMPOUNDS
The present invention relates to a compound of formula (I) (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.