cas 468-07-5, phenomorphan | Articles data ｜lookchem

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468-07-5

Articles about 468-07-5Total 1 be found

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Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: Synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan
A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (μ, δ, and κ) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the μ and κ opioid receptors was observed. All of these novel derivatives showed a preference for the μ and κ versus δ binding.
Neumeyer, John L,Gu, Xiao-Hui,Van Vliet,DeNunzio, Nicholas J,Rusovici, Daniela E,Cohen, Dana J,Negus,Mello, Nancy K,Bidlack, Jean M
p. 2735 - 2740
(2007/10/03)

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Chemical Properties

Melting Point: 243-245°
Boiling Point: 515.1°Cat760mmHg
Flash Point:260.6°C
Density: 1.18g/cm³
Vapor Pressure: 3.13E-11mmHg at 25°C
PKA: pKa 7.30(50% aq EtOH) (Uncertain)
PSA: 23.47000
LogP: 4.63120

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