- PROCESS FOR PREPARING 5-(FLUORO-4-IMINO-3-METHYL)-1-TOSYL-3,4 DIHYDROPYRIMIDINE -(1H)-ONE
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The present invention provides a process for preparing a compound having the formula (I): wherein R is alkyl or alkylaryl; each of X1, X2, X3, X4 and X5 is, independently, H, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, dialkylamino, alkoxycarbonyl, alkyl carbonyl, hydroxyalkyl, ester, acid, halogen, -SH, -OH, -NH2, -NO2, -CN or CF3; Y is O or S; and and Z is a halogen.
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- N-Alkylation of Cytosine and Its Nucleosides with Trialkyl Phosphates
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Cytosine has been readily alkylated with trialkyl phosphates to give the corresponding N-alkyl derivatives, trimethyl phosphate being especially useful for the N-methylation of the base moiety of cytosine nucleosides.
- Hayashi, Masahiro,Yamauchi, Kiyoshi,Kinoshita, Masayoshi
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p. 277 - 278
(2007/10/02)
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