- Thiamin Acetate, C12H17N4OS+.C2H3O2-
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In thiamin acetate crystals, the thiamin cation -5-(2-hydroxyethyl)-4-methylthiazolium> adopts the usual F conformation, with torsion angles C5'-C3,5'-N3-C2 and N3-C3,5-C5'-C4' (between the pyridinyl and thiazolium moieties) of 5.6(7) and -83.5(6) deg, respectively.Hydrogen bonds involving the O5γ-H hydroxyl and N4α'-H2 amine groups and the N1' and N3' pyrimidine atoms interconnect the thiamin cations.The acetate anions are hydrogen bonded to the N4α'-H2 group and probably also to the C2-H group of the thiazole ring.
- Casas, Jose S.,Castineiras, Alfonso,Couce, Maria D.,Sordo, Jose,Varela, Jose M.
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- Preparation method of thiamine mononitrate
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The invention discloses a preparation method of thiamine mononitrate. The preparation method comprises the steps that thiothiamine is oxidized by hydrogen peroxide to obtain thiamine mononitrate, thenthe thiamine mononitrate is converted into salt by using dilute nitric acid and neutralized by using ammonium hydroxide, and finally, cooling, crystallization, filtration and separation are carried out to obtain a thiamine mononitrate solid. The preparation method of the thiamine mononitrate has the advantages that the viewpoint of salt conversion by the ammonium nitrate is improved, the potential safety hazards caused by the use of a large number of the thiamine mononitrate solid during production are avoided, and the step of the preparation of the ammonium nitrate is reduced; on the premiseof not affecting the product quality and yield, the natural stacking density of thiamine mononitrate crystals is improved; the process steps are simple, the production cost is low, control is easy, the stability is good, the particle size is moderate, the degree of purification is high, and industrial large-scale production is facilitated.
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Paragraph 0040-0063
(2019/07/10)
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- A nitric-acid thiamine new synthesis mode (by machine translation)
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The invention discloses a method for nitric acid thiamine new synthesis mode, characterized in that the sulfur on behalf of the thiamine by hydrogen peroxide oxidation of oxidizing liquid, rotation of calcium salt, to obtain calcium sulphate solids separation, then the use of ammonia and in [...], get the nitric acid thiamine, after separation, in the mother liquor contains only ammonium sulfate, through three-effect evaporation to obtain pure ammonium sulfate. The invention disclosed nitric acid thiamine new synthetic way improves the traditional view of converting the ammonium nitrate, calcium transfer salt, not only in the yield and quality has not been affected, but also for later mother liquor and processing has the great advantage of, there is a by-product calcium sulfate generation, there is a pure ammonium sulfate generation, can solve the traditional process the mother liquor in the thiamine nitrate high ammonia nitrogen situation. (by machine translation)
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Paragraph 0015; 0016; 0017; 0018
(2018/05/01)
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- Preparation method for bulk crystal product of thiamine nitrate
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The present invention discloses a preparation method for a bulk crystal product of thiamine nitrate. The method comprises: adding solid thiothiamine into acidic distilled water with pH=2-6, adding hydrogen peroxide dropwise thereto based on mass fraction with stirring, carrying out reaction, oxidation and decolorization to obtain a thiamine sulfate solution; adding a solution of 40-60 wt% ammonium nitrate to the obtained solution from the above oxidation reaction, and an additive is added with stirring and mixing; When ammonia liquor is used to adjust pH to 3.9-4.3, adding a thiamine nitrate seed and growning for 0.5-2 h, continuing to adjust pH to 6.80-7.05, followed by lowering a temperature to 5 DEG C at a rate of 0.5 DEG C/min; and filtering, washing, and driying to obtain a thiamine nitrate crystal. The product is a bulk crystal with an aspect ratio of 1:1 to 4:1, a bulk density of 0.80-0.93 g/mL, and an angle of repose of 25 DEC to 38 DEC, and has better fluidity, and crystal properties are significantly improved. The preparation process is simple, and is easy for industrialization.
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Paragraph 0034; 0035; 0036; 0037
(2016/11/28)
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