- Evaluation of electron or charge transfer processes between chromenylium-based fluorophores and protonated-deprotonated aniline
-
Three functional dyes based on a chromenylium skeleton were prepared. The chromenylium-based fluorophores were regarded as acceptor parts and the aniline served as donor parts; their pH-dependent fluorescent responses were used to evaluate the photoinduce
- Xiao, Jin-Wei,Zhu, Wei-Jin,Sun, Ru,Xu, Yu-Jie,Ge, Jian-Feng
-
-
Read Online
- Lappaconitine derivative with analgesic activity, and preparation method and application thereof
-
The invention provides a lappaconitine derivative with analgesic activity, and a preparation method and application thereof. The structure of the lappaconitine derivative is as shown in formula I in the specification. The lappaconitine derivative provided by the invention is high in analgesic activity, good in water solubility and low in biotoxicity, can be used for preparing low-toxicity analgesic drugs, and is wide in application prospect.
- -
-
Paragraph 0257-0262
(2021/07/14)
-
- Preparation method of tetraethyl michler's ketone
-
The invention relates to a preparation method of tetraethyl Michler's ketone, which comprises the following steps: carrying out acylating chlorination reaction on N, N-diethylaniline and triphosgene as raw materials in a solvent to obtain a reaction intermediate product, then taking a supported catalyst containing Lewis acid as a catalyst, and carrying out reaction on the reaction intermediate product and the N, N-diethylaniline to obtain a target reaction product, namely tetraethyl michler's ketone. Side reactions can be effectively reduced, so that the yield of the target product is increased. After the reaction is finished, the catalyst is collected through solid-liquid separation, so that the separation efficiency is high, and subsequent cyclic utilization is facilitated.
- -
-
Paragraph 0019; 0072; 0074
(2021/04/29)
-
- Compound and color filter
-
The problem of the present invention, when manufacturing a color filter manufacturing process 200 degrees or more if required to heat, a change in hue of the pigmented material is small. (I) a formula: [1 A] (I) (In the general formula (I), A:D -/su
- -
-
Paragraph 0110; 0111
(2019/04/03)
-
- Compound and color filter
-
PROBLEM TO BE SOLVED: To provide a triarylmethane compound having high contrast and excellent color tone and a color filter containing the compound. SOLUTION: The present invention provides a triarylmethane compound represented by formula 2 and a color filter containing a compound represented by the compound as a coloring material. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
- -
-
Paragraph 0104; 0105
(2019/09/06)
-
- Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators
-
Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4-NKX2-5 transcriptional synergy. Here, the chemical space around the molecular structure of 1 was explored by synthesizing and characterizing 220 derivatives and structurally related compounds. In addition to the synergistic transcriptional activation, selected compounds were evaluated for their effects on transcriptional activities of GATA4 and NKX2-5 individually as well as potential cytotoxicity. The structure-activity relationship (SAR) analysis revealed that the aromatic isoxazole substituent in the southern part regulates the inhibition of GATA4-NKX2-5 transcriptional synergy. Moreover, inhibition of GATA4 transcriptional activity correlated with the reduced cell viability. In summary, comprehensive SAR analysis accompanied by data analysis successfully identified potent and selective inhibitors of GATA4-NKX2-5 transcriptional synergy and revealed structural features important for it.
- Jumppanen, Mikael,Kinnunen, Sini M.,V?lim?ki, Mika J.,Talman, Virpi,Auno, Samuli,Bruun, Tanja,Boije Af Genn?s, Gustav,Xhaard, Henri,Aumüller, Ingo B.,Ruskoaho, Heikki,Yli-Kauhaluoma, Jari
-
supporting information
p. 8284 - 8310
(2019/10/11)
-
- Dimer-type triarylmethane dye compounds, blue resin composition comprising the same for color filter and color filter using the same
-
The present invention relates to a blue dye compound for a color filter, and more particularly, to a novel dimer-type triarylmethane dye compound having enhanced solubility, high heat resistance, high light resistance and high brightness compared to a conventional dye, and to a blue resin composition for a color filter comprising the same and a color filter using the same. When the dimer type triarylmethane dye compound according to the present invention is used in the blue resin composition for a color filter, a dye compound which has excellent solubility in propylene glycol monomethyl ether acetate (PGMEA) used as a solvent in a process and which has high heat resistance and high brightness can be provided. Therefore, a color filter with high brightness and a high contrast ratio compared to the conventional pigment type color filter can be manufactured through the manufacture of color filters using the same.(AA) Compound 6(BB) Compound 7(CC) Compound 8(DD) Compound 9(EE) Compound 10(FF) Compound 11(GG) Compound 12COPYRIGHT KIPO 2018
- -
-
Paragraph 0052-0056
(2018/05/03)
-
- Compound and color filter
-
PROBLEM TO BE SOLVED: To provide a triarylmethane compound capable of providing a coloring material that shows little changes in a hue even when the coloring material is subjected to a thermal history at 200 degrees or more required in a process of manufacturing a color filter, for example, capable of providing a liquid crystal display device or the like that can perform excellent liquid crystal display with little changes in a hue, when the compound is used for preparing a blue pixel part of a color filter, and a color filter comprising the above compound. SOLUTION: The triarylmethane compound comprises a basic polymerized triarylmethane dye cation having a specific structure and a specific counter anion. By using the triarylmethane compound as a coloring material of a color filter, the coloring material shows little changes in a hue even when subjected to a thermal history in the process of manufacturing a color filter. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
- -
-
Paragraph 0118
(2017/06/08)
-
- Compound and color filter
-
PROBLEM TO BE SOLVED: To provide a compound becoming a coloring material less in color tone change even with receiving heat history of 200 degree or more required for a manufacturing process during manufacturing a color filter. SOLUTION: There is provided a triarylmethane compound for example represented by the following formula, consisting of basic polymerized triarylmethane dye cation and tris(trifluoromethanesulfonyl)methide anion obtained by exchanging counter anion after condensing a bisindole compound having a 4,4'-bis(phenyl-methyl-amino) substituted benzophenone compound and a phenylene spacer part by phosphorous oxychloride. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
- -
-
Paragraph 0119; 0120
(2017/08/18)
-
- COLOR MATERIAL DISPERSION LIQUID, COLORING RESIN COMPOSITION FOR COLOR FILTER, COLOR FILTER, LIQUID CRYSTAL DISPLAY DEVICE AND LUMINESCENT DISPLAY DEVICE
-
PROBLEM TO BE SOLVED: To provide a color material dispersion liquid useful for a color filter having excellent heat resistance. SOLUTION: A color material dispersion liquid includes: a dialkyl aminobenzophenone compound in which an electron-donating group
- -
-
Paragraph 0129
(2017/11/01)
-
- Compound and color filter
-
PROBLEM TO BE SOLVED: To provide a triarylmethane pigment composition which can give colored matter exhibiting little hue change even when exposed under photoirradiation over a long period of time.SOLUTION: There is disclosed a pigment composition includi
- -
-
Paragraph 0131
(2017/04/22)
-
- Blue dye compounds, colored resin composition comprising the same for color filter and color filter using the same
-
Disclosed is a blue dye compound for a color filter represented by Chemical Formula 1. The blue colored resin composition including the blue dye compound has excellent solubility to an organic solvent, such as propylene glycol methyl ether acetate (PGMEA)
- -
-
Paragraph 0068-0074
(2016/11/28)
-
- Blue dye compounds, colored resin composition comprising the same for color filter and color filter using the same
-
The present invention relates to a blue dye compound for color filters, which is denoted by chemical formula 1. A blue resin composition including the blue dye compound according to the present invention has an outstanding solubility for an organic solven
- -
-
Paragraph 0069
(2016/11/28)
-
- Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action
-
The related 3C and 3C-like proteinase (3Cpro and 3CLpro) of picornaviruses and coronaviruses, respectively, are good drug targets. As part of an effort to generate broad-spectrum inhibitors of these enzymes, we screened a library of inhibitors based on a halopyridinyl ester from a previous study of the severe acute respiratory syndrome (SARS) 3CL proteinase against Hepatitis A virus (HAV) 3Cpro. Three of the compounds, which also had furan rings, inhibited the cleavage activity of HAV 3Cpro with Kics of 120-240 nM. HPLC-based assays revealed that the inhibitors were slowly hydrolyzed by both HAV 3Cpro and SARS 3CLpro, confirming the identity of the expected products. Mass spectrometric analyses indicated that this hydrolysis proceeded via an acyl-enzyme intermediate. Modeling studies indicated that the halopyridinyl moiety of the inhibitor fits tightly into the S1-binding pocket, consistent with the lack of tolerance of the inhibitors to modification in this portion of the molecule. These compounds are among the most potent non-peptidic inhibitors reported to date against a 3Cpro.
- Huitema, Carly,Zhang, Jianmin,Yin, Jiang,James, Michael N.G.,Vederas, John C.,Eltis, Lindsay D.
-
p. 5761 - 5777
(2008/12/21)
-
- Intramolecular charge transfer dual fluorescent sensors from 4-(dialkylamino)benzanilides with metal binding site within electron acceptor
-
Three fluoroionophores (2a-c) were designed as the intramolecular charge transfer (CT) dual fluorescent sensors for metal cations with metal binding site within the electron acceptor. These sensors were derived from 4-dialkylaminobenzanilides (alkyl=methyl, ethyl, and n-butyl) with the amido phenyl ring being an arm of 15-crown-5 thus bearing binding site for alkaline and alkaline earth metal cations. Compounds 2a-c were expected to have two possible CT channels of opposite direction. The absorption and fluorescence spectra of 2a-c and their crown-ether free model molecules 3a-c in a variety of solvents were recorded. Dual fluorescence was observed with 2a-c and was assigned to the LE and the CT states, respectively. In nonpolar or less polar solvents the CT occurring with 2a-c was identified as that occurred with benzanilides (BA) with the amido anilines being the electron donor (the BA-like CT), while in polar solvents such as acetonitrile (ACN), the CT was still mainly the BA-like. In the presence of alkali and alkaline earth metal cations in ACN, the CT dual fluorescence underwent substantial changes so as increased total quantum yield, red-shifted LE band and enhanced CT to LE intensity ratio. Binding of the metal cations at the 15-crown-5 moiety of 2a-c was shown to turn the CT direction that the dialkylamino group in the binding complexes being the electron donor while the benzo-15-crown-5 moiety now being within the electron acceptor. The occurrence of this CT enhances metal cation binding to 15-crown-5 ether in 2a-c, which was confirmed by the observed higher metal binding constants. Compounds 2a-c as the CT dual fluorescent sensors were shown to operate under the mechanism of the metal cation binding induced switching of the CT character from the BA-like to that occurred with 4-(dimethylamino)benzamides (the DMABA-like). Compounds 2a-c therefore represent successful examples for the CT dual fluorescent sensors for cations with the metal binding site within the electron acceptor and can be employed as sensitive ratiometric fluorescent sensors for metal cations of improved sensing performance.
- Liu, Li-Hong,Zhang, Han,Li, Ai-Fang,Xie, Jian-Wei,Jiang, Yun-Bao
-
p. 10441 - 10449
(2007/10/03)
-
- Electronic control of enantioselectivity in the palladium-catalyzed asymmetric allylic substitution of trans 4-tbutyl-1-vinylcyclohexyl benzoates
-
The enantioselectivity in the palladium-catalyzed substitution of allylic benzoates I by sodium dimethylmalonate was influenced by polar and steric effects of the substituents in the phenyl ring of the benzoate. Electron- donating p-substituents afforded
- Legros,Fiaud
-
p. 465 - 474
(2007/10/02)
-