Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-5α-cholestan-15-one and its 14β-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity
3β-Hydroxy-5α-cholestan-15-one (2a) and its 14β-epimer 2b were prepared from 3β-acetoxy-5α-cholest-8(14)-ene (3). Hydroboration of 3 at 45-50°C gave a mixture of 5α,14α-cholestane-3β,15α-diol and 5α,14β-cholestane-3β,15β-diol, which were separated on sili
Siddiqui,Wilson,Parish,Gerst,Pinkerton,Schroepfer Jr.
p. 1 - 15
(2007/10/02)
Stereochemical Course of the Catalytic Reduction and of the Acidic Isomerization of 14β Steroids. Synthesis of Δ8-14β and 8α,9α,14β-Steroids
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Anastasia, Mario,Fiecchi, Alberto,Gariboldi, Pierluigi,Galli, Giovanni
p. 2528 - 2531
(2007/10/02)
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