- Synthesis and biological evaluation of new curcumin analogs inhibiting osteoclastogenesis
-
A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (1a) and the corresponding pyrazine derivat
- Kawano, Tomikazu,Matsumoto, Naomi,Nakanishi-Matsui, Mayumi,Ogawa, Satoshi,Ohashi, Toshika,Sugawara, Aoi,Tamura, Satoru
-
p. 1233 - 1247
(2020/09/18)
-
- Decarboxylative Csp3-Csp3 coupling for benzylation of unstable ketone enolates: Synthesis of: P -(acylethyl)phenols
-
A new decarboxylative Csp3-Csp3 coupling approach for the benzylation of ketone enolates has been developed. A variety of raspberry ketone derivatives were conveniently synthesized in good to excellent yields under mild conditions. A crossover reaction shed light on the mechanism of this tandem reaction.
- Wang, Sasa,Chen, Xinzheng,Ao, Qiaoqiao,Wang, Huifei,Zhai, Hongbin
-
supporting information
p. 9454 - 9457
(2016/07/29)
-
- Synthesis of Two Natural Furan-Cyclized Diarylheptanoids via 2-Furaldehyde
-
Two natural diarylheptanoids, 2-benzyl-5-(2-phenylethyl)furan (1) and 2-methoxy-4-{[5-(2-phenylethyl)furan-2-yl]methyl}phenol (2), were synthesized starting from 2-furaldehyde. A Wittig reaction of 2-furaldehyde with benzyltriphenylphosphonium bromide followed by reduction of the alkene C=C bond with Mg gave 2-(2-phenylethyl)furan (5). Lithiation of 5 with BuLi at -78 followed by alkylation with benzyl bromide gave natural product 1. In another approach, Friedel-Crafts acylation of compound 5 with benzoyl chloride followed by deoxygenation of the C=O group afforded 1. The natural product 2 was also synthesized by acylation of 5 with 4-acetoxy-3-methoxybenzoyl chloride (16) followed by deoxygenation and deacetylation.
- Se?inti, Hatice,Se?en, Hasan
-
p. 938 - 944
(2015/11/23)
-
- CeCl3·7H2O-promoted highly chemoselective hydrolysis of 1,3-oxathio- and dithioacetals
-
A highly selective hydrolysis of the 1,3-oxathio- and 1,3-dithioacetals has been achieved in high yields using CeCl3·7H2O-NaI in acetonitrile at reflux temperature under neutral conditions. This method is mild and compatible with a wide range of functional groups such as TBDPS, THP, PMB, MOM, allyl, propargyl, prenyl, benzyl ethers, carbamates and acetate, etc., present in the substrate.
- Yadav,Reddy,Raghavendra,Satyanarayana
-
p. 4679 - 4681
(2007/10/03)
-
- (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metbotropic glutamate mGluR1 receptors
-
The synthesis of three novel 4-carboxyphenylglycine (LY367385) selectively antagoises metabotropic glutamate mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385.
- Clark, Barry P.,Baker, S. Richard,Goldsworthy, John,Harris, John R.,Kingston, Ann E.
-
p. 2777 - 2780
(2007/10/03)
-