- Preparation method of 5-fluorine-3-aminopyridine
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The invention discloses a preparation method of 5-fluorine-3-aminopyridine, and belongs to the technical field of pyridine compounds. The preparation method is characterized by comprising the following steps: adding 5-fluoronicotinamide into a hypohalite solution dropwise, and then stirring at 0 to 100 DEG C until a TLC reaction is completed; after the solution is cooled to room temperature, adding a sodium hydroxide solution, continuously stirring for 20 to 40 min, and performing filtering and drying to obtain a 5-fluorine-3-aminopyridine solid. The preparation method not only has a safe operation process, is easy and convenient and has low requirements for production equipment, but also is suitable for enlarging the production on the basis of guaranteeing the product quality and high yield.
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