Chemical Reactions of Cycloalkanespirohydantoins. Part 2. Synthesis of New 4-Hydroxyimidazolidinone N3-Substituted from Cycloalkanespirohydantoins
N3-Substituted hydantoins have been to undergo lithium aluminum hydride reduction (THF, room temperature, 5 hours) to give 4-hydroxy-2-imidazolidinones in good yields.
Salazar, Loreto,Rubido, Julia,Espada, Modesta,Pedregal, Carmen,Trigo, Gregorio,Elguero, Jose
p. 481 - 485
(2007/10/02)
Some N3-substituted and N1,N3-disubstituted derivatives of cyclohexanespirohydantoin
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Pedregal,Trigo,Espada,et al.
p. 477 - 480
(2007/10/02)
Method of treating asthma with alkyl, alkylidene and alkylene hydantoins
Pharmaceutical formulations are described, which comprise a hydantoin of formula (I): STR1 wherein R1 is C1-4 alkyl, R2 is hydrogen or C1-4 alkyl; or R1 and R2 taken together either represent a C4-6 alkylene group or a group of formula: STR2 where R5 and R6 independently represent hydrogen or C1-4 alkyl; R3 is C1-6 alkyl or benzyl; R4 is hydrogen or C1-6 alkyl; provided that R2 and R4 cannot both be hydrogen; or R1 and R4 taken together represent a C2-4 alkylene group; associated with a pharmaceutically-acceptable carrier therefor. The compounds, some of which are novel, are useful in the treatment of immediate hypersensitivity diseases such as asthma.