- 1,2-dicarbonyl compound and synthesis method thereof
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The invention discloses a method for synthesizing a 1,2-dicarbonyl compound (1,2-dicarbonylamide or alpha-diketone compound), wherein 1,2-dicarbonyl thioester compounds used as 1,2-dicarbonyl reagentsreact with amine compounds or boric anhydride compounds under appropriate conditions to respectively synthesize a series of 1,2-dicarbonyl compounds. According to the present invention, the 1,2-dicarbonyl compound is obtained by using the stable 1,2-dicarbonyl thioester compound as the dicarbonylation reagent through one-step construction under mild conditions, such that the disadvantage that thetraditional method uses the unstable alpha-carbonyl acyl chloride to synthesize the 1,2-dicarbonyl compound is avoided.
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Paragraph 0155; 0148-0151
(2019/10/01)
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- Reversible diastereoselective photocyclization of phenylglyoxylamides of α-amino acid methyl esters to 3-hydroxy β-lactams
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Phenylglyoxylamides 1a-m were prepared from enantiomerically pure (1b-l) α-amino acid methyl esters in high yields and irradiated in acetonitrile solutions with λ = 300 nm to give the β-lactams 2a-m as photocyclization products in moderate (38 and 40perce
- Griesbeck,Heckroth
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p. 131 - 133
(2007/10/03)
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- Stereochimie de la reduction electrochimique d'α-cetoamides optiquement actives II. Electroreduction de benzoylformamides derives de la S(-)-proline
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Electrochemical reduction of benzoylformamides derived from S-(-)-proline has been carried out at a mercury cathode in a buffered hydroalcoholic medium; quantitative formation of a mixture of the two epimers of the corresponding mandelamides is observed.D
- Boulmedais, Ali,Jubault, Michel,Tallec, Andre
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p. 185 - 191
(2007/10/02)
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- Diastereoselective Reduction of Chiral α-Ketoamides Derived from (S)-Proline Esters with Sodium Borohydride. Preparation of Optically Active α-Hydroxy Acids
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Diastereoselective reductions of chiral α-ketoamides (3) derived from (S)-proline esters (2) with sodium borohydride were examined.Hydrolysis of the reduction products afforded optically active α-hydroxy acids (5) in good enantiomeric excesses (e.e.).The most influential factor of the asymmetric induction was the effect of using a mixed hydroxylic and non-hydroxylic solvent.The degree of asymmetric induction varied considerably with the ratio of alcohol and tetrahydrofuran (THF) in the mixed solvent.With aromatic ketoamides (3), higher asymmetric induction occured in a mixed alcohol-THF solvent than in the corresponding individual solvents.
- Soai, Kenso,Hasegawa, Hitoshi
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p. 769 - 772
(2007/10/02)
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