Suzuki-miyaura cross-coupling reactions in flow: Multistep synthesis enabled by a microfluidic extraction
Continuous success: A continuous-flow Suzuki-Miyaura cross-coupling reaction starting from phenols was made possible through use of an efficient microfluidic extraction operation and a packed-bed reactor. Various biaryls were obtained in excellent yield (
Noal, Timothy,Kuhn, Simon,Musacchio, Andrew J.,Jensen, Klavs F.,Buchwald, Stephen L.
supporting information; experimental part
p. 5943 - 5946
(2011/08/02)
Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride
A simple and facile method for the cleavage of carbon-oxygen bonds promoted by niobium pentachloride(V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt(V), and a neighboring-group effect may play a significant role in the regioselectivity. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Sudo, Yukinori,Arai, Shigeru,Nishida, Atsushi
p. 752 - 758
(2007/10/03)
Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
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Page/Page column 11
(2008/06/13)
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