- 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11?-HSD1 inhibitors for the treatment of diabetes
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Racemic cis-1,1-dioxo-5,6-dihydro-[4,1,2]oxathiazine derivative 4a was isolated as an impurity in a sample of a hit from a HTS campaign on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). After separation by chiral chromatography the 4a-S, 8a-R enantio
- B?hme, Thomas,Engel, Christian K.,Farjot, Géraldine,Güssregen, Stefan,Haack, Torsten,Tschank, Georg,Ritter, Kurt
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p. 4685 - 4691
(2013/08/15)
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- Acyl and Sulfonyl Isocyanates ib β-Lactam Synthesis
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The preparation of β-lactams from the reactions of several acyl and sulfonyl activated isocyanates with alkenes was studied.Three compounds, (2,2,2-trichloroethoxy)sulfonyl, 2,2,2-trichloroethane sulfonyl, and trifluoroacetyl isocyanates, were shown to be
- Barrett, Anthony G. M.,Betts, Michael J.,Fenwick, Ashley
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p. 169 - 175
(2007/10/02)
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