A new (R)-hydroxynitrile lyase from Prunus mume: Asymmetric synthesis of cyanohydrins
A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay technique was developed for the enzyme, which promotes the addition of KCN to benzaldehyde in a buffered solution (pH=4.5).
Nanda, Samik,Kato, Yasuo,Asano, Yasuhisa
p. 10908 - 10916
(2007/10/03)
Enzymatic Preparation of Optically Active Cyanohydrin Acetates
A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.
Almsick, Andreas van,Buddrus, Joachim,Hoenicke-Schmidt, Petra,Laumen, Kurt,Schneider, Manfred P.
p. 1391 - 1393
(2007/10/02)
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