106086-78-6

Basic information

• Product Name: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE
• Synonyms: 2-(BROMOMETHYL)BENZOTHIAZOLE;2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE;2-(Bromomethyl)benzothiazole, 98+%;2-(bromomethyl)benzo[d]thiazole;2-(Bromomethyl)-1,3-benzothiazole ,95%;Benzothiazole,2-(broMoMethyl)-;2-BroMoMethyl benzothizaole;[(Benzo[d]thiazol-2-yl)methyl]bromide
• CAS NO: 106086-78-6
• Molecular Formula: C₈H₆BrNS
• Molecular Weight: 228.11
• Mol File: 106086-78-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 47 °C
• Boiling Point: 288℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.680
• Vapor Pressure: 0.00408mmHg at 25°C
• Refractive Index: 1.713
• Storage Temp.: 2-8°C
• PKA: 0.38±0.10(Predicted)
• CAS DataBase Reference: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE(106086-78-6)
• EPA Substance Registry System: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE(106086-78-6)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 34-41-37/38-22
• Safety Statements: 26-36/37/39-36/37/3945-39
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 106086-78-6(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-1,3-benzothiazole is a chemical compound with the molecular formula C8H6BrNS. It is a benzothiazole derivative with a bromomethyl group attached to the 2-position of the benzene ring. 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. It is also used as a building block for the preparation of fluorescent dyes and as a reagent in organic synthesis. Additionally, 2-(bromomethyl)-1,3-benzothiazole has been studied for its potential antimicrobial, antifungal, and antitumor properties. However, it is important to handle this compound with care, as it is a potential irritant and may cause harmful effects if ingested or inhaled.

InChI:InChI=1/C8H6BrNS/c9-5-8-10-6-3-1-2-4-7(6)11-8/h1-4H,5H2

Upstream product

• 37859-42-0 1,3-benzothiazol-2-ylmethanol 
• 598-21-0 2-Bromoacetyl bromide 
• 1074-18-6 N-ethyl-o-aminothiophenol 
• 120-75-2 2-Methylbenzothiazole 
• 40070-39-1 triethyl orthobromoacetate 
• 137-07-5 2-amino-benzenethiol 
• 6639-57-2 benzothiazole-2-carbaldehyde 

Downstream Products

• 100537-61-9 2-((4-nitrophenoxy)methyl)benzothiazole 
• 100537-48-2 2-((4-nitrophenylthio)methyl)benzothiazole 
• 187272-95-3 4-(benzo[d]thiazol-2-ylmethoxy)benzaldehyde 
• 37859-41-9 N-(benzothiazol-2-ylmethyl)-N-ethylethanamine 
• 42182-65-0 1,3-benzothiazol-2-ylmethanamine 
• 138786-50-2 2-<(3-cyanophenoxy)methyl>benzothiazole 
• 86321-58-6 2-ethoxymethyl-1,3-benzothiazole 
• 704862-32-8 O-(benzo[d]thiazol-2-ylmethyl)hydroxylamine 
• 17681-30-0 1-(benzo[d]thiazol-2-yl)-N-methylmethanamine 
• 197359-84-5 N-[4-(benzothiazol-2-ylmethoxy)phenyl]acetamide 
• 197360-05-7 N-[4-(Benzothiazol-2-ylmethylthio)phenyl]acetamide 
• 1351411-91-0 2-((4-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)phenyl)piperazin-1-yl)methyl)benzo[d]thiazole 
• 1351411-92-1 2-(2-(4-(benzo[d]thiazol-2-ylmethyl)piperazin-1-yl)phenoxy)ethanol 
• 1351411-93-2 2-(2-(4-(benzo[d]thiazol-2-ylmethyl)piperazin-1-yl)phenoxy)ethyl 4-methyl-benzenesulfonate 

Relevant articles and documents

Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study

BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55Gag or CA, by means of surface plasmon resonance. The synthesized Bi

Synthesis and theoretical study of a new type of pentacyclic bis-benzothiazolium compound

The synthesis of a new type of pentacyclic benzothiazolium compound-6,13-dihydropyrazino[2,1-b:5,4-b′]bis(1,3-benzothiazole)-7, 14-diiumdibromide (2), is reported. Compound 2 was prepared by dimerization of 2-(bromomethyl)benzothiazole. Quantum chemical calculation studies have been carried out on the structures of possible isomers of 2, as well as the products of its deprotonation reactions.

AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES

In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF

In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.