129954-34-3

Basic information

• Product Name: Selank peptide
• Synonyms: Selank peptide;SelankAcetate
• CAS NO: 129954-34-3
• Molecular Formula: C33H57N11O9
• Molecular Weight: 751.87
• EINECS: -0
• Mol File: 129954-34-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 134-136 °C
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 3.43±0.20(Predicted)
• CAS DataBase Reference: Selank peptide(CAS DataBase Reference)
• NIST Chemistry Reference: Selank peptide(129954-34-3)
• EPA Substance Registry System: Selank peptide(129954-34-3)

Safety Data

• Hazardous Substances Data: 129954-34-3(Hazardous Substances Data)

Usage

Description

Selank peptide is a synthetic derivative of the tetrapeptide tuftsin, characterized by a proline-glycine-proline sequence at the C-terminus. It exhibits anxiolytic and anti-inflammatory properties, making it a promising candidate for various applications in different industries.
Used in Pharmaceutical Industry:
Selank peptide is used as an anxiolytic agent for its ability to decrease the level of affective responses and the number of erroneous escape attempts in rats under acute stress. It also increases orientational-investigative responses in unfamiliar situations and reduces the time mice spend immobile in the forced swim test.
Selank peptide is used as an anti-inflammatory agent for its capacity to decrease the expression of inflammation-related genes Il2rg and Xcr1 in mouse spleen when administered at a specific dose.
Used in Neuropharmacology Research:
Selank peptide is used as a research tool for studying the effects of peptides on neuronal activity, as it increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region at a concentration of 1 μM.
Used in Behavioral Studies:
Selank peptide is used in behavioral studies to assess its impact on locomotor activity in high-anxiety Balb/c mice in the open field test, where it has been observed to increase their activity.
Used in Preclinical Models:
Selank peptide is used in preclinical models to evaluate its potential therapeutic effects on conditions such as anxiety and inflammation, as well as its ability to modulate specific biological pathways and gene expressions.