142847-18-5Relevant articles and documents
Naamines and naamidines as novel agents against a plant virus and phytopathogenic fungi
Guo, Pengbin,Li, Gang,Liu, Yuxiu,Lu, Aidang,Wang, Ziwen,Wang, Qingmin
, (2018/09/13)
Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%.
Synthesis of l - Epi -capreomycidine derivatives via C-H amination
Tanino, Tetsuya,Ichikawa, Satoshi,Matsuda, Akira
supporting information; experimental part, p. 4028 - 4031 (2011/10/04)
The l-epi-capreomycidine (Cpm) derivatives were efficiently and stereoselectively synthesized via nitrene C-H insertion starting from a readily available d-Tyr. Design of a substrate that takes into account hydrogen bonding is a critical feature in order
Synthesis of tyrosine-derived tetrahydroisoquinolines by Lewis acid catalyzed cyclization of N-(phenylsulfonyl)alkyloxazolidinones
Tussetschlaeger, Stefan,Baro, Angelika,Laschat, Sabine,Frey, Wolfgang
, p. 5590 - 5602 (2008/09/17)
N-Boc-protected tyrosine esters 5a,b were converted into tetrahydroisoquinolines 13 and 14 in four steps by reduction and ring closure to oxazolidinones 9 and 10, addition of benzenesulfinic acid and aldehydes to sulfones 11 and 12 and subsequent Lewis ac