Welcome to LookChem.com Sign In|Join Free

CAS

  • or

149809-43-8

Post Buying Request

149809-43-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Manufacturer/High quality/Best price/In stock

    Cas No: 149809-43-8

  • USD $ 3.0-3.0 / Kilogram

  • 1 Kilogram

  • 1-100 Metric Ton/Month

  • Dayang Chem (Hangzhou) Co.,Ltd.
  • Contact Supplier
  • High quality (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester supplier in China

    Cas No: 149809-43-8

  • No Data

  • 1 Metric Ton

  • 30 Metric Ton/Month

  • Simagchem Corporation
  • Contact Supplier
  • High purity Various Specifications (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester CAS:149809-43-8

    Cas No: 149809-43-8

  • USD $ 100.0-500.0 / Gram

  • 1 Gram

  • 99999 Gram/Year

  • Hangzhou Dingyan Chem Co., Ltd
  • Contact Supplier
  • (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

    Cas No: 149809-43-8

  • USD $ 45.0-45.0 / Gram

  • 1 Gram

  • 200 Metric Ton/Year

  • Jinan Finer Chemical Co., Ltd
  • Contact Supplier
  • Good quality (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

    Cas No: 149809-43-8

  • No Data

  • 1 Kilogram

  • 1 Metric Ton/Month

  • Hangzhou Think Chemical Co. Ltd
  • Contact Supplier

149809-43-8 Usage

Description

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a complex organic compound with a unique chemical structure. It is characterized as a white crystalline solid and is primarily known for its role as an intermediate in the synthesis of posaconazole, a potent antifungal agent.

Uses

1. Used in Pharmaceutical Industry:
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is used as an intermediate in the synthesis of posaconazole for its antifungal properties. Posaconazole is effective against a wide range of fungal infections, making it a valuable compound in the development of antifungal medications.
2. Used in Antifungal Applications:
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester contributes to the development of posaconazole, which is employed as an antifungal agent. It is particularly useful in treating invasive fungal infections, such as aspergillosis and candidiasis, in immunocompromised patients.

Check Digit Verification of cas no

The CAS Registry Mumber 149809-43-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,8,0 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 149809-43:
(8*1)+(7*4)+(6*9)+(5*8)+(4*0)+(3*9)+(2*4)+(1*3)=168
168 % 10 = 8
So 149809-43-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H21F2N3O4S/c1-15-2-5-18(6-3-15)31(27,28)30-11-16-9-21(29-10-16,12-26-14-24-13-25-26)19-7-4-17(22)8-20(19)23/h2-8,13-14,16H,9-12H2,1H3/t16-,21-/m0/s1

149809-43-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-methylbenzenesulfonate

1.2 Other means of identification

Product number -
Other names 6-Methoxyaromadendrin 3-O-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149809-43-8 SDS

149809-43-8Relevant articles and documents

Preparation method of posaconazole intermediate

-

, (2021/11/21)

The invention relates to the technical field of medicine preparation, and especially relates to a preparation method of a posaconazole intermediate. The preparation method comprises the following steps: reacting a compound as shown in a formula II, serving as a raw material, with 1, 2, 4-triazole to obtain a compound as shown in a formula III, and then reacting with air or oxygen under the action of a catalyst 1 to obtain a compound as shown in a formula IV; reacting the compound as shown in the formula IV with dimethyl malonate to obtain a compound as shown in a formula V; reacting the compound shown in the formula V under the action of a reducing agent to obtain a compound shown in a formula VI; and finally, carrying out intramolecular etherification reaction on the compound shown in the formula VI, and carrying out sulfonylation reaction on the obtained product to obtain a target product I. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, few reaction steps, high yield and high purity of the obtained product.

Preparation method for preparing posaconazole midbody

-

, (2017/08/27)

The invention provides a method for preparing a posaconazole midbody shown as the formula 1. According to the preparation method, a compound 2 reported in literature is used as a raw material; firstly, trialkyl silane is used for protecting hydroxyl to obtain a compound 3; then, the compound 3 takes a reaction with sodium salts 4 of triazole to obtain a compound 5; next, siloxane removal is performed under the effects of paratoluensulfonyl chloride and alkali, and toluenesulfonyl protection is performed to obtain a compound 1. The method provided by the invention can overcome the defects in the prior art; a splicing step is not performed; the occurrence of side reaction and the appearance of impurities are reduced; the reaction selectivity and the yield are improved. The formulas are shown as the accompanying drawing.

Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof

-

Paragraph 0322; 0323, (2014/12/09)

A process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof. (I)

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 149809-43-8