157355-79-8

Basic information

• Product Name: FMOC-D-HIS-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-HISTIDINE;FMOC-D-HIS-OH;FMOC-D-HISTIDINE;N-α-Fmoc-D-histidine;Fmoc-D-His;Nalpha-Fmoc-D-histidine;Nα-Fmoc-D-histidine≥ 99% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl D-His-OH
• CAS NO: 157355-79-8
• Molecular Formula: C₂₁H₁₉N₃O₄
• Molecular Weight: 377.39
• Mol File: 157355-79-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 706.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.372±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Acetic Acid (Slightly), Aqueous Base (Slightly), DMSO (Slightly), DMF (Slightly,
• PKA: 3.26±0.10(Predicted)
• CAS DataBase Reference: FMOC-D-HIS-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-HIS-OH(157355-79-8)
• EPA Substance Registry System: FMOC-D-HIS-OH(157355-79-8)

Safety Data

• Hazardous Substances Data: 157355-79-8(Hazardous Substances Data)

Usage

Description

FMOC-D-HIS-OH, also known as Nα-Fmoc-D-histidine, is an N-Fmoc-protected form of D-Histidine (H456015). D-Histidine is the unnatural, biologically inactive isomer of L-Histidine (H456010). It is an off-white solid and has unique properties that make it useful in various applications.

Uses

Used in Pharmaceutical Industry:
FMOC-D-HIS-OH is used as a building block for the synthesis of peptides and other bioactive molecules. Its application reason is due to its ability to inhibit cell division and its role as a source of L-Histidine in certain types of bacteria, such as Escherichia coli.
Used in Chemical Synthesis:
FMOC-D-HIS-OH is used as a protected amino acid in chemical synthesis processes. The application reason is its stability and reactivity, which allows for the creation of complex molecular structures with controlled functional groups.
Used in Research and Development:
FMOC-D-HIS-OH is used as a research tool for studying the properties and functions of histidine and its derivatives. The application reason is its unique chemical properties, which provide insights into the mechanisms of cell division and the role of histidine in biological processes.
Used in Drug Development:
FMOC-D-HIS-OH is used as a potential therapeutic agent in drug development. The application reason is its ability to inhibit cell division, which may have implications for the treatment of certain diseases and conditions.

Relevant articles and documents

Esterification of 4-alkoxybenzyl alcohol resin with FMOC-histidine(Nim-trityl)-N-carboxyanhydride

Esterification of 4-Alkoxybenzyl alcohol resin (Wang resin) is accomplished rapidly in high yield and with no detectable racemization when FMOC-histidine(Nim-trityl)-NCA is the condensing reagent.