166737-85-5

Basic information

• Product Name: H-L-CYS(TRT)-NH2 HCL
• Synonyms: S-TRITYL-L-CYSTEINE AMIDE HYDROCHLORIDE;H-L-CYS(TRT)-NH2 HCL;H-Cys(Trt)-NH2;(R)-2-amino-3-(tritylthio)propanamide hydrochloride;H-Cys(Trt)-NH2.HCl;S-Trityl-L-cysteinamide hydrochloride;S-Trityl-L-cysteinaMide, 98%;PropanaMide,2-aMino-3-[(triphenylMethyl)thio]-, (2R)-
• CAS NO: 166737-85-5
• Molecular Formula: C₂₂H₂₂N₂OS
• Molecular Weight: 398.95
• Product Categories: Pharmaceutical Intermediates
• Mol File: 166737-85-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 531.681 °C at 760 mmHg
• Flash Point: 275.351 °C
• Appearance: Off-white/Powder
• Density: 1.183 g/cm³
• Vapor Pressure: 2.19E-11mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.83±0.50(Predicted)
• CAS DataBase Reference: H-L-CYS(TRT)-NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-L-CYS(TRT)-NH2 HCL(166737-85-5)
• EPA Substance Registry System: H-L-CYS(TRT)-NH2 HCL(166737-85-5)

Safety Data

• Hazardous Substances Data: 166737-85-5(Hazardous Substances Data)

Usage

Description

H-L-CYS(TRT)-NH2 HCL, also known as (2R)-2-Amino-3-[(triphenylmethyl)thio]propanamide, is a white to off-white powder that serves as a useful building block for organic synthesis. Its unique chemical structure, featuring an amino group and a triphenylmethylthio group, makes it a versatile compound for various applications in different industries.

Uses

Used in Organic Synthesis:
H-L-CYS(TRT)-NH2 HCL is used as a building block in organic synthesis for its ability to form a wide range of chemical compounds. Its reactivity and functional groups allow for the creation of new molecules with diverse properties and applications.
Used in Pharmaceutical Industry:
H-L-CYS(TRT)-NH2 HCL is used as an intermediate in the synthesis of pharmaceutical compounds for its potential therapeutic properties. Its unique structure can be incorporated into drug molecules to enhance their efficacy, selectivity, and pharmacokinetic properties.
Used in Chemical Research:
H-L-CYS(TRT)-NH2 HCL is used as a research tool in chemical laboratories for studying the properties and reactions of various organic compounds. Its versatility and reactivity make it an ideal candidate for investigating new chemical reactions and mechanisms.
Used in Material Science:
H-L-CYS(TRT)-NH2 HCL is used in the development of new materials with specific properties, such as conductivity, stability, or biocompatibility. Its unique structure can be incorporated into polymers, coatings, or other materials to impart desired characteristics.

InChI:InChI=1/C22H22N2OS/c23-21(25)20(16-26)24-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20,24,26H,16H2,(H2,23,25)/t20-/m0/s1

Upstream product

• 103213-32-7 N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine 
• 202752-01-0 (R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(triphenylmethylthio)propan-2-yl)carbamate 
• 97802-29-4 C(Trt) 
• 58885-35-1 S-trityl-L-cysteine methyl ether 

Downstream Products

• 1064622-45-2 N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinamide 
• 942057-11-6 (R)-allyl (1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamate 

Relevant articles and documents

Synthesis method of S-trityl-L-cysteinamide

The invention relates to a synthesis method of S-trityl-L-cysteinamide. The method mainly solves the technical problem of product racemization in the existing synthesis method. The preparation method comprises the following three steps: step 1, adding CDI into a tetrahydrofuran solution of (+)-S-trityl-L-cysteine, stirring to react for 4 hours, and adding ammonia water to obtain a compound 1; 2, the compound 1 reacts with piperidine in N, N-dimethylformamide to obtain a compound 2; and 3, dissolving the compound 2 in ethyl acetate, adding L-dibenzoyl tartaric acid to form salt, measuring that ee is greater than 99.0%, and alkalifying to obtain a pure compound 3.

Aminothiol compound, preparation method of aminothiol compound and application of aminothiol compound in radiation protection

The invention discloses an aminothiol compound, a preparation method of the aminothiol compound and application of the aminothiol compound in radiation protection. The compound has a structure shown in the formula I in the description, wherein A1 is selected from -C(O)NR8-, -S(O)2-NR8-, -S(O)NR8- and -R7-NR8-, A2 is selected from carbonyl, sulfonyl, sulfinyl and substituted or unsubstituted C1-6 alkyl, R1, R2, R5 and R6 can be the same or not and are selected from hydrogen and substituted or unsubstituted C1-C5 alkyl or hetero alkyl, n is an integer from 0 to 20000, R3 and R4 are independently selected from hydrogen, X and substituted or unsubstituted C1-6 alkyl, X is selected from F, Cl, Br and I, R7 is selected from substituted or unsubstituted C1-C6 alkyl, and R8 is selected from hydrogen and substituted or unsubstituted C1-C6 alkyl. The compound has the effect of reducing biological injury caused by ionizing radiation and also has the effects of prolonging the lifetime of radiated animals and increasing the survival rate of the radiated animals.

ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS

Compounds of formula (B): (1a), or (1b), (1c) are provided wherein the variables are as defined herein which are useful in disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple