201004-29-7 Usage
Description
FMOC-LYS(ME3)-OH HCL, also known as Fmoc protected N-trimethyl lysine, is a common N-terminal protected reagent used in peptide synthesis. It is a white to off-white powder with specific chemical properties that make it suitable for various applications in the field of biochemistry and pharmaceuticals.
Uses
Used in Peptide Synthesis:
FMOC-LYS(ME3)-OH HCL is used as a protected amino acid in peptide synthesis for the incorporation of N-trimethyl lysine residues into peptide sequences. Its protection allows for selective deprotection and coupling during the synthesis process, facilitating the creation of complex peptide structures.
Used in Bioconjugation:
FMOC-LYS(ME3)-OH HCL is used as a building block in the synthesis of peptide linkers for monoclonal antibody-drug conjugates, such as monoclonal antibody-auristatin F conjugates. These conjugates are designed to deliver potent drugs specifically to cancer cells, improving the therapeutic index and reducing side effects.
Used in Analytical Chemistry:
FMOC-LYS(ME3)-OH HCL is used as a component in the preparation of multifunctional reagents with enhanced ionization properties. These reagents are employed for the analysis of protein modifications in human cells and dynamic profiling of protein lipidation, aiding in the study of cellular processes and disease mechanisms.
Used in Protein Synthesis:
FMOC-LYS(ME3)-OH HCL is utilized in sequential peptide ligation techniques to synthesize modified proteins, such as histone H3 containing a trimethyl lysine residue with a modified tail region. This allows for the investigation of the role of specific protein modifications in chromatin structure and function, as well as their implications in various biological processes and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 201004-29-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,0,0 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 201004-29:
(8*2)+(7*0)+(6*1)+(5*0)+(4*0)+(3*4)+(2*2)+(1*9)=47
47 % 10 = 7
So 201004-29-7 is a valid CAS Registry Number.
201004-29-7Relevant articles and documents
Development of a fluorogenic probe with a transesterification switch for detection of histone deacetylase activity
Baba, Reisuke,Hori, Yuichiro,Mizukami, Shin,Kikuchi, Kazuya
, p. 14310 - 14313 (2012)
Histone deacetylases (HDACs) are key enzymatic regulators of many cellular processes such as gene expression, cell cycle, and tumorigenesis. These enzymes are attractive targets for drug development. However, very few simple methods for monitoring HDAC ac
Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition
Belle, Roman,Al Temimi, Abbas H. K.,Kumar, Kiran,Pieters, Bas J. G. E.,Tumber, Anthony,Dunford, James E.,Johansson, Catrine,Oppermann, Udo,Brown, Tom,Schofield, Christopher J.,Hopkinson, Richard J.,Paton, Robert S.,Kawamura, Akane,Mecinovi?, Jasmin
supporting information, p. 13264 - 13267 (2017/12/26)
Histone lysine methylation is regulated by N?-methyltransferases, demethylases, and N?-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigen