214907-09-2

Basic information

• Product Name: 4,6-diamino-5-iodopyrimidine
• Synonyms: 4,6-diamino-5-iodopyrimidine;5-Iodopyrimidine-4,6-diamine
• CAS NO: 214907-09-2
• Molecular Formula: C₄H₅IN₄
• Molecular Weight: 236.01377
• Mol File: 214907-09-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.4±45.0 °C(Predicted)
• Appearance: /
• Density: 2.302±0.06 g/cm3(Predicted)
• PKA: 4.25±0.10(Predicted)
• CAS DataBase Reference: 4,6-diamino-5-iodopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-diamino-5-iodopyrimidine(214907-09-2)
• EPA Substance Registry System: 4,6-diamino-5-iodopyrimidine(214907-09-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Hazardous Substances Data: 214907-09-2(Hazardous Substances Data)

Usage

General Description

4,6-diamino-5-iodopyrimidine is a chemical compound with the molecular formula C4H4N4I. It is a derivative of pyrimidine, a six-membered heterocyclic ring containing four carbon atoms and two nitrogen atoms. The compound is characterized by the presence of two amino groups (-NH2) and one iodine atom. It has potential applications in organic synthesis and pharmaceuticals, particularly in the development of antiviral and anticancer drugs. Additionally, 4,6-diamino-5-iodopyrimidine is used as a building block in the synthesis of various heterocyclic compounds and is a valuable intermediate in the production of specialty chemicals.

Upstream product

• 2434-56-2 4,6-diaminopyrimidine 

Downstream Products

• 857287-03-7 5-[(3-aminophenyl)ethynyl]pyrimidine-4,6-diamine 
• 876955-11-2 5-[(E)-3-(3-Bromo-phenyl)-propenyl]-pyrimidine-4,6-diamine 
• 876954-79-9 5-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876955-06-5 5-((E)-4-Phenyl-but-1-enyl)-pyrimidine-4,6-diamine 
• 876954-80-2 5-[(E)-2-(4-Bromo-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876954-91-5 5-[(E)-2-(3-Bromo-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876955-02-1 5-[(E)-2-(3-Methoxy-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876955-03-2 5-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 859211-31-7 5-[2-(3-bromo-4-methoxyphenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876955-04-3 5-((E)-Styryl)-pyrimidine-4,6-diamine 
• 1026452-16-3 5-[(E)-1,2-Bis-(3-fluoro-4-methyl-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 1026455-81-1 5-((E)-1,2-Diphenyl-vinyl)-pyrimidine-4,6-diamine 
• 876955-01-0 5-[(E)-2-(4-Methoxy-phenyl)-vinyl]-pyrimidine-4,6-diamine 
• 876955-10-1 5-(p-methyl-styryl)-4,6-diaminopyrimidine 

Relevant articles and documents

Synthesis and photophysical evaluation of new fluorescent 7-arylethynyl-7-deazaadenosine analogs

Three new fluorescent 7-deaza-2′-deoxyadenosine analogs were synthesized via the Sonogashira cross-coupling reaction of 7-iodo-7-deaza-2′-deoxyadenosine with 1-ethynylpyrene, 2-ethynyl-6-methoxynaphthalene, and 9-ethynylphenanthrene. The spectral properties of these analogs were evaluated in dioxane, EtOH, and H2O to determine their potential for use as environmentally sensitive fluorescent probes. All three analogs displayed large solvatofluorochromicity in H2O, relative to their emission wavelengths in dioxane or EtOH. Moreover, all three analogs exhibited microenvironmental sensitivity of their fluorescence emission intensity, being moderate to high quantum yields in dioxane and EtOH and significantly lower in H2O. Various attempts to perform domino cross-coupling and annuation reactions on 7-deaza-7-alkynyladenine derivatives to form a new fused tricyclic adenine analog were unsuccessful.

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates

Nucleoside phosphoramidates (NPs) are a class of nucleotide analogues that has been developed as potential antiviral/antitumor prodrugs. Recently, we have shown that some amino acid nucleoside phosphoramidates (aaNPs) can act as substrates for viral polymerases like HIV-1 RT. Herein, we report the synthesis and hydrolysis of a series of new aaNPs, containing either natural or modified nucleobases to define the basis for their differential reactivity. Aqueous stability, kinetics, and hydrolysis pathways were studied by NMR spectroscopy at different solution pD values (5-7) and temperatures. It was observed that the kinetics and mechanism (P-N and/or P-O bond cleavage) of the hydrolysis reaction largely depend on the nature of the nucleobase and amino acid moieties. Aspartyl NPs were found to be more reactive than Gly or β-Ala NPs. For aspartyl NPs, the order of reactivity of the nucleobase was 1-deazaadenine>7- deazaadenine>adenine>thymine≥3-deazaadenine. Notably, neutral aqueous solutions of Asp-1-deaza-dAMP degraded spontaneously even at 4°C through exclusive P-O bond hydrolysis (a 50-fold reactivity difference for Asp-1-deaza-dAMP vs. Asp-3-deaza-dAMP at pD 5 and 70°C). Conformational studies by NMR spectroscopy and molecular modeling suggest the involvement of the protonated N3 atom in adenine and 1- and 7-deazaadenine in the intramolecular catalysis of the hydrolysis reaction through the rare syn conformation. Touching (nucleo)base: A dual intramolecular catalytic influence is demonstrated by the nucleobase and carboxyl groups in the chemical hydrolysis of amino acid nucleoside phosphoramidate prodrugs (see scheme). The replacement of the adenine N1 or N7 atoms instead of the N3 atom is shown to have a conformational role in which the protonated N3 is crucial in regulating the kinetics and mechanism of nucleotide (P-N pathway) versus nucleoside (P-O pathway) formation. Copyright

Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido [2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor

Adenosine (ADO) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. Inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO, selectively increases ADO concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ADO. Optimization of the high-throughput screening lead, 4-amino-7-aryl-substituted pteridine (5) (AK IC50 = 440 nM), led to the identification of compound 21 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido [2,3-d]pyrimidine, ABT-702), a novel, potent (AK IC50 = 1.7 nM) nonnucleoside AK inhibitor with oral activity in animal models of pain and inflammation.